免疫球蛋白G、A和M共有的重链可变区亚类，其特征为氨基末端残基未被封闭。
A variable region subclass of heavy chains common to immunoglobulins G, A, and M and characterized by an unblocked amino-terminal residue.
作者信息
Wang A C, Pink J R, Fudenberg H H, Ohms J
出版信息
Proc Natl Acad Sci U S A. 1970 Jul;66(3):657-63. doi: 10.1073/pnas.66.3.657.
Abstract
Heavy chains of IgG, IgA, and IgM classes of human immunoglobulins were compared by N-terminal residue determination and partial amino acid sequence analysis. A third subclass of the variable region of heavy chains was observed; an unblocked glutamic acid as the N-terminal residue is characteristic of this subclass. Our results indicated that the heavy chain variable region subclasses are not class specific, and that a given heavy chain variable region may be found in association with constant regions for mu-chains, alpha-chains, or gamma-chains of various subclasses.
摘要
通过N端残基测定和部分氨基酸序列分析，对人免疫球蛋白IgG、IgA和IgM类的重链进行了比较。观察到重链可变区的第三个亚类；以未封闭的谷氨酸作为N端残基是该亚类的特征。我们的结果表明，重链可变区亚类不是类别特异性的，并且给定的重链可变区可能与不同亚类的μ链、α链或γ链的恒定区相关联。
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A variable region subclass of heavy chains common to immunoglobulins G, A, and M and characterized by an unblocked amino-terminal residue.免疫球蛋白G、A和M共有的重链可变区亚类，其特征为氨基末端残基未被封闭。
Proc Natl Acad Sci U S A. 1970 Jul;66(3):657-63. doi: 10.1073/pnas.66.3.657.
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