慢性复发性实验性变应性脑脊髓炎：致敏时年龄对临床病程和病理学的影响。

Chronic relapsing experimental allergic encephalomyelitis: effect of age at the time of sensitization on clinical course and pathology.

作者信息

Lassmann H, Wisniewski H M

出版信息

Acta Neuropathol. 1979 Jul 13;47(2):111-6. doi: 10.1007/BF00717033.

Abstract

Experimental allergic encephalomyelitis was induced by sensitization with guinea pig spinal cord in complete Freund's adjuvant with increased content of myobacterium in Hartley guinea pigs between the first and 28th day after birth. The animals either died during acute EAE or showed chronic progressive, chronic relapsing or chronic EAE with delayed onset. In animals immunized between the 1 and 13 day after birth, predominatly ordinary and chronic progressive EAE was noted, whereas animals sensitized between the 14th and 23rd day frequently suffered from hyperacute or chronic relapsing EAE. Immunization on the 24th day led to very high mortality in acute EAE. The relation of the pathohistologic alterations to different types of human inflammatory demyelinative disease is discussed.

摘要

在出生后第1天至第28天之间，用含分枝杆菌量增加的完全弗氏佐剂中的豚鼠脊髓致敏，诱导Hartley豚鼠发生实验性变应性脑脊髓炎。动物要么在急性实验性变应性脑脊髓炎期间死亡，要么表现为慢性进行性、慢性复发性或迟发性慢性实验性变应性脑脊髓炎。在出生后第1天至第13天免疫的动物中，主要观察到普通型和慢性进行性实验性变应性脑脊髓炎，而在第14天至第23天致敏的动物经常患有超急性或慢性复发性实验性变应性脑脊髓炎。在第24天进行免疫导致急性实验性变应性脑脊髓炎的死亡率非常高。讨论了病理组织学改变与不同类型人类炎性脱髓鞘疾病的关系。