Knave B, Mindus P, Struwe G
Acta Psychiatr Scand. 1979 Jul;60(1):39-49. doi: 10.1111/j.1600-0447.1979.tb00263.x.
Long-term exposure to petroleum distillation products (e.g. jet fuel) has been suggested to cause chronic mental and neurological symptoms. In the present "cross-sectional epidemiological study" the extent of neuropsychiatric ill-health in 30 workers exposed to jet fuel was compared with that in 60 non-exposed matched controls. Standardized medical interviews showed a higher occurrence of neurasthenic symptoms in exposed subjects (P less than 0.001). The result was confirmed by examination of the medical records kept by the factory physician (P less than 0.01). The prevalence of psychiatric symptoms was assessed with a rating scale of 37 items (a modified CPRS). Again, the exposed workers scored higher than the controls (P less than 0.001), particularly regarding the neurasthenic symptoms, i.e. fatigue, anxiety, mood changes, memory difficulties, and various psychosomatic symptoms (P less than 0.01). The results could neither be explained by observer's bias, nor by a greater susceptibility for mental disorders in the exposed subjects. We therefore conclude that occupational exposure to jet fuel vapours around the present threshold limit values may induce a neurasthenic syndrome.
长期接触石油蒸馏产品（如喷气燃料）被认为会导致慢性精神和神经症状。在目前的“横断面流行病学研究”中，将30名接触喷气燃料的工人的神经精神健康不良程度与60名未接触的匹配对照组进行了比较。标准化医学访谈显示，接触组受试者神经衰弱症状的发生率更高（P<0.001）。工厂医生保存的病历检查证实了这一结果（P<0.01）。用一个37项的评定量表（改良的CPRS）评估精神症状的患病率。同样，接触组工人的得分高于对照组（P<0.001），尤其是在神经衰弱症状方面，即疲劳、焦虑、情绪变化、记忆困难和各种心身症状（P<0.01）。结果既不能用观察者偏差来解释，也不能用接触组受试者对精神障碍的易感性更高来解释。因此，我们得出结论，在当前阈限值附近职业接触喷气燃料蒸气可能会诱发神经衰弱综合征。
