Tolagen K
Scand J Clin Lab Invest. 1978 Sep;38(5):487-93. doi: 10.1080/00365517809108455.
Plasma aldosterone (PA) and urinary aldosterone (Aldo-U) concentrations were studied in 123 patients with primary (essential) hypertension during basal (1 h supine rest), upright and frusemide (80 mg orally) stimulated conditions, and were related to urinary sodium and potassium excretions, supine and sitting blood pressure (BP) and the relationship to plasma renin activity (PRA). As controls, 120 normotensive subjects, matched for age and sex, were investigated identically during strictly defined out-patient conditions. No differences regarding the different mean PA levels, urinary electrolyte excretion or the urinary sodium: potassium ratio were observed between the hypertensive and the normotensive populations. However, the hypertensive subjects had significantly higher mean Aldo-U excretions than the controls. Correlations between PA and the corresponding PRA were consistently significant in the normotensive control group but weak to non-existent in the hypertensive subjects. No relationships at all could be found between the different PRA and Aldo-U values in the hypertensive population but significant correlations were noted in the control group. These findings point to a disturbed function of the renin-angiotensin-aldosterone (RAA) system even in primary hypertension.
对123例原发性（特发性）高血压患者在基础状态（仰卧休息1小时）、直立位以及口服速尿（80毫克）刺激状态下的血浆醛固酮（PA）和尿醛固酮（Aldo-U）浓度进行了研究，并将其与尿钠和钾排泄量、仰卧位和坐位血压（BP）以及与血浆肾素活性（PRA）的关系进行了关联分析。作为对照，对120名年龄和性别匹配的血压正常受试者在严格界定的门诊条件下进行了相同的研究。在高血压人群和血压正常人群之间，未观察到不同平均PA水平、尿电解质排泄或尿钠钾比值存在差异。然而，高血压患者的平均Aldo-U排泄量显著高于对照组。在血压正常的对照组中，PA与相应的PRA之间的相关性始终显著，但在高血压患者中则较弱或不存在。在高血压人群中，不同的PRA与Aldo-U值之间未发现任何关系，但在对照组中观察到显著相关性。这些发现表明，即使在原发性高血压中，肾素-血管紧张素-醛固酮（RAA）系统的功能也受到了干扰。
