McCrae W M, Eastwood M A, Martin M R, Sircus W
Lancet. 1975 Jan 25;1(7900):187-90. doi: 10.1016/s0140-6736(75)91358-6.
A review has been carried out of patients diagnosed as having coeliac disease some years previously and subsequently lost to follow-up. Most were unaware of the need for continuing treatment and had returned to a normal diet. The resulting morbidity was slight, although one patient had died of a small-bowel lymphoma. If untreated coeliac disease is indeed a pre-malignant condition, then it is suggested that there must be a large population at risk, with no motivation to return to treatment other than the risk of malignancy itself.
对几年前被诊断患有乳糜泻但随后失去随访的患者进行了一项回顾性研究。大多数患者不知道需要持续治疗,并且已经恢复了正常饮食。由此产生的发病率较低,尽管有一名患者死于小肠淋巴瘤。如果未经治疗的乳糜泻确实是一种癌前病变,那么表明必然有大量处于风险中的人群,除了恶性肿瘤本身的风险外,没有动力恢复治疗。