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长期给予尼古丁对雄性Fischer-344大鼠肝脏、睾丸和脂肪组织中脂肪酸分布无影响。

Lack of effect of chronic nicotine administration on fatty acid distribution in the liver, testis, and adipose tissue of male Fischer-344 rats.

作者信息

Brindis R G, Petersen B J, Thompson J H, Alfin-Slater R B

出版信息

J Lipid Res. 1973 Nov;14(6):688-91.

PMID:4742562
Abstract

A comparison is made of the percentage compositions of major fatty acids in liver and testis phospholipids, liver and abdominal adipose tissue triglycerides, and liver sterol esters in male Fischer-344 rats administered a physiological saline control or a "smoking" dose of nicotine (1000 micro g base/kg/day, subcutaneously) for 2 or 22 months. Results indicate that there is no major trend, or significant difference, between nicotine- or saline-treated rats with respect to major fatty acid distribution. Some differences in fatty acid distribution in the various lipid fractions were found between young and old rats.

摘要

对给予生理盐水对照或“吸烟”剂量尼古丁(1000微克碱/千克/天,皮下注射)2个月或22个月的雄性Fischer-344大鼠的肝脏和睾丸磷脂、肝脏和腹部脂肪组织甘油三酯以及肝脏固醇酯中的主要脂肪酸百分比组成进行了比较。结果表明,在主要脂肪酸分布方面,尼古丁处理组和生理盐水处理组大鼠之间没有主要趋势或显著差异。在年轻和老年大鼠之间发现了各种脂质组分中脂肪酸分布的一些差异。

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J Lipid Res. 1973 Nov;14(6):688-91.
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