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组蛋白对豚鼠接种A-爱知-2-68（H3N2）流感病毒后抗体反应的影响。

Influence of histones on the antibody response in guinea pigs to vaccination with A-Aichi-2-68 (H3 N2) influenza virus.

作者信息

Drescher J, Gillissen G

出版信息

Infect Immun. 1973 Oct;8(4):573-6. doi: 10.1128/iai.8.4.573-576.1973.

DOI:10.1128/iai.8.4.573-576.1973
PMID:4742973
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC422893/
Abstract

The influence of total, F1, and F3 histones on the primary antibody response in guinea pigs to vaccination with influenza virus A/2/Aichi/2/68 (H3 N2) was investigated. It was found that histones can greatly reduce the immunoglobulin (Ig) M and, to a smaller degree, the IgG antibody response. The immunosuppressive effect of histones was found to depend critically on the dose of virus used for vaccination, on the type and dose of histones, and on the schedule of histone application.

摘要

研究了总组蛋白、F1组蛋白和F3组蛋白对豚鼠针对甲型流感病毒A/2/爱知/2/68（H3N2）疫苗接种的初次抗体反应的影响。结果发现，组蛋白可显著降低免疫球蛋白（Ig）M抗体反应，对IgG抗体反应的降低程度较小。还发现组蛋白的免疫抑制作用严重依赖于用于疫苗接种的病毒剂量、组蛋白的类型和剂量以及组蛋白的应用方案。

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1
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Infect Immun. 1973 Oct;8(4):573-6. doi: 10.1128/iai.8.4.573-576.1973.
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本文引用的文献

1
Further fractionations of histones from calf thymus.来自小牛胸腺组蛋白的进一步分级分离。
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J Immunol. 1967 Jun;98(6):1182-9.
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The antigenic subunits of influenza viruses. I. The homologous antibody response.流感病毒的抗原亚单位。I. 同源抗体反应。
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[Effect exerted by a histone fraction (P II) on the formation of antibodies].[组蛋白组分（P II）对抗体形成的作用]
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8
[Immunosuppressive effect of histone on the model of skin transplantation. Comparative studies with cyclophosphamide].[组蛋白对皮肤移植模型的免疫抑制作用。与环磷酰胺的比较研究]
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Rabbit precipitin antibody to chicken erythrocyte histone F2C.针对鸡红细胞组蛋白F2C的兔沉淀素抗体。
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