Rosenblatt S, Leighton W P, Chanley J D
Science. 1973 Nov 20;182(4115):923-4. doi: 10.1126/science.182.4115.923.
Tritiated dopamine was infused into psychiatric patients during acute psychotic episodes and in remission. An index of the activity of dopamine-beta-hydroxylase of salivary gland sympathetic neurons was determined by measuring the distribution of tritiated metabolites in salivary fluid. Increased synthesis of norepinephrine occurred in acute schizophrenia and in the manic state of manic-depressive psychosis but not in the depressed phase.
在急性精神病发作期和缓解期，向精神疾病患者体内注入氚标记的多巴胺。通过测量唾液中氚标记代谢物的分布来确定唾液腺交感神经元多巴胺-β-羟化酶的活性指标。去甲肾上腺素合成增加发生在急性精神分裂症和躁狂抑郁症的躁狂状态，但在抑郁期未出现。
