Markianos E S, Nyström I, Reichel H, Matussek N
Psychopharmacology (Berl). 1976 Nov 24;50(3):259-67. doi: 10.1007/BF00426842.
Serum dopamine-beta-hydroxylase activity was estimated in groups of normals and of psychiatric patients, using a thin layer radiochromatographic method. The percentage of patients with schizophrenic and with depressive symptomatology was higher in the population with high enzyme activities. In addition, d-amphetamine given to normals caused an increase in the serum activity while haloperidol caused the opposite effect. The activity in serum is interpreted as a loss in the enzyme from the place it acts physiologically, with possible influence on the noradrenaline synthesis rate.
采用薄层放射色谱法对正常人群和精神疾病患者群体的血清多巴胺-β-羟化酶活性进行了评估。酶活性高的人群中，有精神分裂症症状和抑郁症状的患者比例更高。此外，给正常人服用右旋苯丙胺会导致血清活性升高，而氟哌啶醇则产生相反的效果。血清中的活性被解释为酶从其生理作用部位流失，可能会影响去甲肾上腺素的合成速率。
