皮下注射弗氏病毒和弗氏脾细胞后小鼠对弗氏病病毒感染的抵抗力。
Resistance of mice to infection with Friend disease virus after subcutaneous injection of Friend virus and Friend spleen cells.
作者信息
Larson C L, Ushijima R N, Kasuga S K, Baker R E, Baker M B
出版信息
Infect Immun. 1973 Nov;8(5):708-14. doi: 10.1128/iai.8.5.708-714.1973.
Abstract
Swiss mice injected subcutaneously with suspensions of spleen cells or an extract of spleens from mice infected with Friend virus develop resistance to subsequent intravenous inoculation of Friend virus. A single injection of either Friend virus or Friend cells induces resistance. Immunized mice display resistance when challenged 6 months after immunization and survive for at least 20 weeks after infection. Neutralization tests indicate that serum, but not lymphoid cells of resistant animals, can neutralize Friend virus. In vitro neutralization tests indicate that residence of virus within the peritoneal cavity of immune mice for 1 h sharply reduces the infective titer of the virus.
摘要
皮下注射感染了Friend病毒的小鼠脾脏细胞悬液或脾脏提取物的瑞士小鼠，对随后静脉注射Friend病毒产生抗性。单次注射Friend病毒或Friend细胞均可诱导抗性。免疫小鼠在免疫6个月后受到攻击时表现出抗性，并在感染后存活至少20周。中和试验表明，抗性动物的血清而非淋巴细胞能够中和Friend病毒。体外中和试验表明，病毒在免疫小鼠腹腔内停留1小时会大幅降低病毒的感染滴度。
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本文引用的文献
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QUANTITATION OF A MURINE LEUKEMIA VIRUS WITH A SPLEEN COLONY ASSAY.用脾集落试验对小鼠白血病病毒进行定量分析。
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IMMUNE REACTIONS TO A MURINE LEUKEMIA VIRUS. I. INDUCTION OF IMMUNITY TO INFECTION WITH VIRUS IN THE NATURAL HOST.对一种小鼠白血病病毒的免疫反应。I. 在自然宿主中诱导对病毒感染的免疫力。
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Resistance of mice infected with Moloney leukemia virus to Friend virus infection.
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