Podolec Z, Vetulani J, Bednarczyk B, Szczeklik A
Allergy. 1979 Apr 2;34(2):103-10. doi: 10.1111/j.1398-9995.1979.tb01370.x.
Dopaminergic agents, dopa and apomorphine, affected biphasically the blood eosinophil count in the rat: low doses of the drug elevated, while high doses lowered it. The response to a high dose of dopa was retained in rats pretreated with an inhibitor of dopamine-beta-hydroxylase, U 10, 157, but prevented by a centrally acting dopa decarboxylase inhibitor, NSD 1015. This indicates that the eosinopenia observed after large doses of dopa is due to the action of dopamine formed from the precursor. As intracerebroventricular injections of Ldopa also produce eosinopenia, the central site of dopamine action is indicated. The eosinopenic response to apomorphine was antagonized by a dopamine receptor blocking agent, haloperidol. This indicates that some central dopamine receptors are involved in the regulation of the eosinophil count in circulating blood. The hypophysis seems to play a crucial role in the phenomenon observed, as no eosinopenia was produced by dopa in hypophysectomized rats.
多巴胺能药物、多巴和阿扑吗啡对大鼠血液嗜酸性粒细胞计数有双相影响：低剂量药物使其升高，而高剂量则使其降低。在用多巴胺-β-羟化酶抑制剂U 10,157预处理的大鼠中，对高剂量多巴的反应仍然存在，但被中枢作用的多巴脱羧酶抑制剂NSD 1015所阻断。这表明大剂量多巴后观察到的嗜酸性粒细胞减少是由于前体形成的多巴胺的作用。由于脑室内注射左旋多巴也会产生嗜酸性粒细胞减少，提示了多巴胺作用的中枢部位。对阿扑吗啡的嗜酸性粒细胞减少反应被多巴胺受体阻断剂氟哌啶醇所拮抗。这表明一些中枢多巴胺受体参与了循环血液中嗜酸性粒细胞计数的调节。垂体似乎在观察到的现象中起关键作用，因为在垂体切除的大鼠中，多巴不会产生嗜酸性粒细胞减少。
