Tryfon Stavros, Saroglou Maria, Kazanas Kosmas, Mermigkis Charalambos, Psathakis Kostas, Galanis Nikolaos
1st Pulmonary Clinic, G,H, "G, Papanikolaou", Thessaloniki, Greece.
J Med Case Rep. 2009 Feb 9;3:51. doi: 10.1186/1752-1947-3-51.
There are few reported cases of neutrophilic pleural effusions associated with valproic acid therapy. Most of them are of eosinophilic exudates with or without blood eosinophilia.
This case study describes a 70-year-old man with recurrent episodes of eosinophilic transudative pleural effusions associated with sodium valproate treatment. The recurrence of effusion after re-administration of the drug is strongly suggestive of an association between them. To the best of our knowledge, this is the first reported case with a pleural effusion with these characteristics caused by sodium valproate.
This is the first report in the literature, with a full understanding of the etiology but with an unknown drug mechanism. This case report is of interest to different medical specialists (such as pulmonologists, neurologists, cardiologists) and pharmacologists.
与丙戊酸治疗相关的中性粒细胞性胸腔积液报告病例较少。其中大多数是嗜酸性渗出液，伴有或不伴有血液嗜酸性粒细胞增多。
本病例研究描述了一名70岁男性，与丙戊酸钠治疗相关，反复出现嗜酸性渗出性胸腔积液。再次给药后积液复发强烈提示它们之间存在关联。据我们所知，这是首例由丙戊酸钠引起的具有这些特征的胸腔积液报告病例。
这是文献中的首例报告，病因明确但药物机制不明。本病例报告引起了不同医学专家（如肺科医生、神经科医生、心脏病专家）和药理学家的关注。
