Andreoli V, Maffei F, Montanaro N, Morandini G
Arzneimittelforschung. 1977 Feb;27(2):436-9.
A group of 20 female neurotic inpatients has been treated with 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one-(chlordesmethyldiazepan)- 7-chloro-5(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one (lorazepam) according to a double-blind cross-over design. For each drug clinical evaluations were performed by means of Hamilton's rating scale for anxiety states and of Overall and Gorham's brief psychiatric rating scale, at the beginning, after the first week and at the end of the two-week period of treatment, in opposite sequence. A statistically greater efficacy of chlordesmethyldiazepam in comparison to lorazepam was observed. Results are discussed with regard to benzodiazepine structure-activity relationships.
一组20名患有神经症的女性住院患者按照双盲交叉设计，接受了7-氯-5-（2-氯苯基）-1,3-二氢-2H-1,4-苯并二氮杂卓-2-酮（去甲氯氮卓）-7-氯-5-（邻氯苯基）-1,3-二氢-3-羟基-2H-1,4-苯并二氮杂卓-2-酮（劳拉西泮）的治疗。对于每种药物，在治疗开始时、第一周后以及两周治疗期结束时，以相反的顺序通过汉密尔顿焦虑量表和奥弗尔与戈尔曼简明精神病评定量表进行临床评估。观察到去甲氯氮卓与劳拉西泮相比在统计学上具有更高的疗效。结合苯二氮卓类药物的构效关系对结果进行了讨论。
