Dubey J P
Am J Vet Res. 1979 May;40(5):698-9.
The effect of fenbendazole therapy was studied in six dogs fed 10,000 embryonated Toxocara canis eggs. At 47 days after they were fed T canis, four dogs were given fenbendazole in two divided doses totaling 50 mg/kg of body weight each day for 14 days. Two infected dogs were not given fenbendazole. All dogs were necropsied at the end of treatment and the foci were counted in the lungs; their skeletal muscles were digested in 1% trypsin for the recovery of larvae. The T canis larvae were not recovered from the skeletal muscle of the four infected dogs treated with fenbendazole; 15 and 42 larvae/100 g of skeletal muscle were recovered from the two nonmedicated infeected dogs. The number of grossly visible foci on surfaces of lungs in treated dogs was markedly less than in the nonmedicated infected dogs. The results indicate that fenbendazole might be effective in preventing prenatal infection in dogs.
研究了芬苯达唑疗法对6只喂食10000个感染性犬弓首蛔虫卵的犬的影响。在给它们喂食犬弓首蛔虫47天后，4只犬每天分两次给予芬苯达唑，每次剂量为50毫克/千克体重，持续14天。2只受感染的犬未给予芬苯达唑。治疗结束时对所有犬进行尸检，并对肺部病灶进行计数；将它们的骨骼肌用1%胰蛋白酶消化以回收幼虫。在用芬苯达唑治疗的4只受感染犬的骨骼肌中未回收犬弓首蛔虫幼虫；从2只未用药的受感染犬中，每100克骨骼肌回收了15条和42条幼虫。治疗犬肺部表面肉眼可见的病灶数量明显少于未用药的受感染犬。结果表明，芬苯达唑可能对预防犬的产前感染有效。
