Dubey J P, Miller T B, Sharma S P
J Am Vet Med Assoc. 1979 Apr 15;174(8):835-7.
The effect of fenbendazole therapy was studied in 9 dogs with pulmonary paragonimiasis induced by inoculation of metacercariae (25/dog) of Paragonimus kellicotti. At 42 to 47 days after 6 dogs were inoculated, they were given fenbendazole in 2 divided doses totaling 50 mg (4 dogs) or 100 mg (2 dogs)/kg of body weight each day for 10 to 14 days. Three dogs were not treated. The passage of Paragonimus eggs in the feces ceased after 3 days at the high dosage and after 3 to 8 days at the low dosage. All dogs were euthanatized and necropsied on day 14. Live flukes were not recovered from the lungs of any treated dog, but 15, 19, and 23 live flukes were recovered from the untreated dogs.
研究了芬苯达唑对9只通过接种凯氏并殖吸虫囊蚴（每只狗接种25个）诱发肺并殖吸虫病的犬的治疗效果。6只狗接种后42至47天，给予芬苯达唑，分2次给药，每天总剂量为50mg（4只狗）或100mg（2只狗）/kg体重，持续10至14天。3只狗未接受治疗。高剂量组在3天后粪便中不再排出并殖吸虫卵，低剂量组在3至8天后不再排出。所有狗在第14天实施安乐死并进行尸检。任何接受治疗的狗的肺中均未发现活吸虫，但未治疗的狗的肺中分别发现15只、19只和23只活吸虫。
