Custer R S, Bush M, Carpenter J W
Am J Vet Res. 1979 Jun;40(6):892-5.
Rate of appearance, peak concentration, and the biological half-life of gentamicin in the plasma of quail (Coturnix coturnix), pheasants (Phasianus colchicus), and cranes (Grus canadensis tabida) were studied. Gentamicin was given IM in doses of 5, 10, and 20 mg/kg of body weight. Peak plasma concentrations occurred earliest in the quail, latest in the cranes. The peak concentrations varied directly with the administered doses in all species. The biological half-life of gentamicin was 42 +/- 12 minutes in the quail, 75 +/- 15 minutes in the pheasants, and 165 +/- 37 minutes in the cranes. On the basis of the present data, dosage regimens for gentaminic of 5 mg/kg every 8 hours in pheasants and cranes, and 10 mg/kg every 6 hours in quail, would be expected to give constant plasma concentrations greater than 4.0 micrograms/ml.
研究了庆大霉素在鹌鹑（日本鹌鹑）、雉鸡（环颈雉）和鹤（加拿大鹤指名亚种）血浆中的出现率、峰值浓度和生物半衰期。庆大霉素以5、10和20毫克/千克体重的剂量肌肉注射。血浆峰值浓度在鹌鹑中出现最早，在鹤中出现最晚。所有物种的峰值浓度均与给药剂量直接相关。庆大霉素的生物半衰期在鹌鹑中为42±12分钟，在雉鸡中为75±15分钟，在鹤中为165±37分钟。根据目前的数据，预计雉鸡和鹤每8小时注射5毫克/千克庆大霉素，鹌鹑每6小时注射10毫克/千克庆大霉素的给药方案将使血浆浓度持续高于4.0微克/毫升。
