Bitsch V
Appl Microbiol. 1973 Sep;26(3):337-43. doi: 10.1128/am.26.3.337-343.1973.
In an experiment with infectious bovine rhinotracheitis (IBR) virus in two bulls, observed over a period of 122 weeks, the pattern of virus release was studied. Recurrent, unprovoked release of virus was demonstrated after one year in a nasal washing from one of the bulls and in preputial washings of both on 13 and 4 occasions, respectively, and finally in weeks 113 and 110, although clinical disease was not observed. During periods of recurrent virus release, concentrations of virus in the prepuce were generally much lower than during the period of primary infection; usually, however, they were not of negligible titer. The frequency of such periods and the virus titers observed strongly suggest that an IBR antibody carrier should always be considered as a potential source of infection to other animals. When virus was demonstrated in semen an almost equal amount was found in the preputial washing (50 ml). In week 120, virus replication in the respiratory tract and prepuce was induced in both bulls by prednisolone injections. It is concluded that antibody carriers will rarely attain a state of absolute immunity.
在一项针对两头公牛进行的传染性牛鼻气管炎（IBR）病毒实验中，观察期为122周，研究了病毒释放模式。一年后，在其中一头公牛的鼻腔冲洗液中以及两头公牛的包皮冲洗液中分别在13次和4次检测到反复、无端的病毒释放，最终在第113周和第110周也检测到了，尽管未观察到临床疾病。在病毒反复释放期间，包皮中病毒浓度通常远低于初次感染期间；然而，通常其滴度并非可忽略不计。此类时期的频率以及观察到的病毒滴度强烈表明，IBR抗体携带者应始终被视为其他动物潜在的感染源。当在精液中检测到病毒时，在包皮冲洗液（50毫升）中发现了几乎等量的病毒。在第120周，通过注射泼尼松龙在两头公牛的呼吸道和包皮中诱导了病毒复制。得出的结论是，抗体携带者很少会达到绝对免疫状态。
