牛疱疹病毒1型持续感染：兔模型
Persistent infection with bovine herpesvirus type 1: rabbit model.
作者信息
Rock D L, Reed D E
出版信息
Infect Immun. 1982 Jan;35(1):371-3. doi: 10.1128/iai.35.1.371-373.1982.
Abstract
Persistent infection with bovine herpesvirus type 1 (BHV-1) was established in all rabbits after conjunctival inoculation of virus. Spontaneous reactivations of BHV-1 with and without the appearance of recurrent ocular lesions were observed in persistently infected rabbits. BHV-1 was reactivated predictably and shed from all persistently infected rabbits after the administration of dexamethasone. During all reactivations, BHV-1 isolation was restricted to the inoculated eye.
摘要
在所有兔子结膜接种牛疱疹病毒1型（BHV - 1）后均建立了持续性感染。在持续感染的兔子中观察到了BHV - 1的自发再激活，有或没有复发性眼部病变出现。给予地塞米松后，BHV - 1在所有持续感染的兔子中可预测地被再激活并排出。在所有再激活过程中，BHV - 1的分离仅限于接种的眼睛。
相似文献
1
Persistent infection with bovine herpesvirus type 1: rabbit model.牛疱疹病毒1型持续感染：兔模型
Infect Immun. 1982 Jan;35(1):371-3. doi: 10.1128/iai.35.1.371-373.1982.
2
Experimental infection of rabbits with bovine herpesvirus-4: acute and persistent infection.用牛疱疹病毒4对兔子进行实验性感染：急性和持续性感染
Vet Microbiol. 1982 Dec;7(6):503-13. doi: 10.1016/0378-1135(82)90045-1.
3
Attempted reactivation of latent bovine herpesvirus 1 infection in calves by infection with ruminant pestiviruses.通过反刍动物瘟病毒感染试图激活犊牛潜伏的牛疱疹病毒1型感染。
Vet Microbiol. 1983 Nov;8(6):563-9. doi: 10.1016/0378-1135(83)90005-6.
4
Attempts to reactivate bovid herpesvirus-2 in experimentally infected calves.在实验感染的犊牛中重新激活牛疱疹病毒2型的尝试。
Am J Vet Res. 1980 Nov;41(11):1890-3.
5
Persistence of bovid herpesvirus-4 in experimentally inoculated pregnant rabbits.牛疱疹病毒4型在实验接种的怀孕兔子中的持续性
New Microbiol. 1993 Jan;16(1):87-93.
6
Establishment of a rabbit model for bovine herpesvirus type 5 neurological acute infection.牛疱疹病毒5型神经急性感染兔模型的建立
Vet Microbiol. 1996 Jul;51(1-2):27-40. doi: 10.1016/0378-1135(96)00016-8.
7
Recrudescence of bovine herpesvirus-5 in experimentally infected calves.牛疱疹病毒5型在实验感染犊牛中的复发
Am J Vet Res. 1982 Feb;43(2):336-8.
8
Neuropathology of bovine herpesvirus type 5 (BHV-5) meningo-encephalitis in a rabbit seizure model.兔癫痫模型中牛疱疹病毒5型（BHV-5）脑膜脑炎的神经病理学
J Comp Pathol. 1997 Nov;117(4):295-310. doi: 10.1016/s0021-9975(97)80078-3.
9
Further studies of naturally occurring latent bovine herpesvirus infection.自然发生的潜伏性牛疱疹病毒感染的进一步研究
Am J Vet Res. 1981 Oct;42(10):1811-3.
10
Latent infection by bovine herpesvirus type-5 in experimentally infected rabbits: virus reactivation, shedding and recrudescence of neurological disease.牛疱疹病毒5型在实验感染兔中的潜伏感染：病毒再激活、排毒及神经疾病复发
Vet Microbiol. 2002 Feb 4;84(4):285-95. doi: 10.1016/s0378-1135(01)00441-2.
引用本文的文献
1
Glucocorticoid receptor occupancy of key bovine alphaherpesvirus 1 (BoHV-1) promoters correlates with chromatin remodeling during reactivation from latency.关键牛α疱疹病毒1型（BoHV-1）启动子的糖皮质激素受体占有率与潜伏再激活过程中的染色质重塑相关。
J Virol. 2025 Aug 19;99(8):e0074725. doi: 10.1128/jvi.00747-25. Epub 2025 Jul 22.
2
Glucocorticoid Receptor (GR) and Specificity Protein 1 (Sp1) or Sp3 Transactivate the Bovine Alphaherpesvirus 1 (BoHV-1)-Infected Cell Protein 0 Early Promoter.糖皮质激素受体（GR）与特异性蛋白1（Sp1）或Sp3可激活牛α疱疹病毒1型（BoHV-1）感染细胞蛋白0早期启动子。
Viruses. 2025 Feb 7;17(2):229. doi: 10.3390/v17020229.
3
Pioneer transcription factors, progesterone receptor and Krüppel like transcription factor 4, cooperatively stimulate the bovine herpesvirus 1 ICP0 early promoter and productive late protein expression.先驱转录因子、孕激素受体和 Krüppel 样转录因子 4 协同刺激牛疱疹病毒 1 ICP0 早期启动子和有产物的晚期蛋白表达。
Virus Res. 2020 Oct 15;288:198115. doi: 10.1016/j.virusres.2020.198115. Epub 2020 Aug 11.
4
Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): infectious bovine rhinotracheitis (IBR).在《动物卫生法》（欧盟第2016/429号条例）框架内对动物疾病进行列名和分类的评估：传染性牛鼻气管炎（IBR）
EFSA J. 2017 Jul 28;15(7):e04947. doi: 10.2903/j.efsa.2017.4947. eCollection 2017 Jul.
5
Progesterone increases the incidence of bovine herpesvirus 1 reactivation from latency and stimulates productive infection.孕酮会增加牛疱疹病毒 1 从潜伏状态重新激活的发生率，并刺激其进行有效感染。
Virus Res. 2020 Jan 15;276:197803. doi: 10.1016/j.virusres.2019.197803. Epub 2019 Nov 4.
6
Role of Sphingomyelin in Alphaherpesvirus Entry.鞘磷脂在α疱疹病毒进入中的作用。
J Virol. 2019 Feb 19;93(5). doi: 10.1128/JVI.01547-18. Print 2019 Mar 1.
7
Persistence and reactivation of bovine herpesvirus 1 in the tonsils of latently infected calves.牛疱疹病毒1在潜伏感染犊牛扁桃体中的持续存在与再激活
J Virol. 2000 Jun;74(11):5337-46. doi: 10.1128/jvi.74.11.5337-5346.2000.
8
Identification of gene products encoded by the latency-related gene of bovine herpesvirus 1.牛疱疹病毒1型潜伏相关基因编码的基因产物的鉴定
J Virol. 1995 Sep;69(9):5345-52. doi: 10.1128/JVI.69.9.5345-5352.1995.
9
Mapping bovine herpesvirus type 1 latency-related RNA in trigeminal ganglia of latently infected rabbits.在潜伏感染兔的三叉神经节中绘制牛疱疹病毒1型潜伏相关RNA图谱。
J Virol. 1987 Dec;61(12):3827-31. doi: 10.1128/JVI.61.12.3827-3831.1987.
10
Herpes simplex virus, type 1 invasion of the rabbit and mouse nervous systems revealed by in situ hybridization.原位杂交揭示单纯疱疹病毒1型对兔和小鼠神经系统的侵袭。
Acta Neuropathol. 1987;74(2):124-32. doi: 10.1007/BF00692842.
本文引用的文献
1
Isolation of bovine herpesvirus-1 from trigeminal ganglia of clinically normal cattle.从临床正常牛的三叉神经节中分离出牛疱疹病毒1型。
Am J Vet Res. 1980 Aug;41(8):1212-3.
2
Evaluation of the rabbit as a laboratory model for infectious bovine rhinotracheitis virus infection.兔作为传染性牛鼻气管炎病毒感染实验室模型的评估。
Cornell Vet. 1980 Jan;70(1):77-95.
3
Experimental infection of maiden heifers by the vagina with infectious bovine rhinotracheitis-infectious pustular vulvo-vaginitis virus. An epidemiological study.用传染性牛鼻气管炎-传染性脓疱性外阴阴道炎病毒经阴道对初产小母牛进行实验性感染。一项流行病学研究。
J Comp Pathol. 1973 Apr;83(2):271-9. doi: 10.1016/0021-9975(73)90052-2.
4
Infectious bovine rhinotracheitis virus infection in bulls, with special reference to preputial infection.公牛感染牛传染性鼻气管炎病毒，特别提及包皮感染。
Appl Microbiol. 1973 Sep;26(3):337-43. doi: 10.1128/am.26.3.337-343.1973.
5
Role of cell-mediated immunity in the recovery of cattle from primary and recurrent infections with infectious bovine rhinotracheitis virus.细胞介导免疫在牛从传染性牛鼻气管炎病毒原发性和复发性感染中恢复过程中的作用
Infect Immun. 1973 Oct;8(4):510-8. doi: 10.1128/iai.8.4.510-518.1973.
6
Reactivation of a bovine herpesvirus after corticosteroid treatment.皮质类固醇治疗后牛疱疹病毒的再激活。
Proc Soc Exp Biol Med. 1972 Jul;140(3):974-6. doi: 10.3181/00379727-140-36592.
7
Neural changes in calves after intraconjunctival inoculation with infectious bovine rhinotracheitis virus.传染性牛鼻气管炎病毒结膜内接种后犊牛的神经变化
J Comp Pathol. 1978 Jul;88(3):387-94. doi: 10.1016/0021-9975(78)90042-7.
8
9
Neural changes in recurrent infection of infectious bovine rhinotracheitis virus in calves treated with dexamethasone.地塞米松治疗的犊牛传染性牛鼻气管炎病毒反复感染中的神经变化。
Am J Vet Res. 1978 Sep;39(9):1399-403.
10
Infectious bovine rhinotracheitis: a review and update.传染性牛鼻气管炎：综述与更新
J Am Vet Med Assoc. 1977 Nov 15;171(10):1055-64.
Zotero 插件