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本文引用的文献

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[Colorimetric determination of 1-(2-hydroxyethyl)-2-methyl-5-nitro-imidazole (metronidazole)].[比色法测定1-(2-羟乙基)-2-甲基-5-硝基咪唑(甲硝唑)]
Ann Pharm Fr. 1968 Jul-Aug;26(7):549-56.
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Effect of metronidazole on hydrogen production by Clostridium acetobutylicum.甲硝唑对丙酮丁醇梭菌产氢的影响。
Arch Mikrobiol. 1972;84(3):225-33. doi: 10.1007/BF00425200.
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Letter: "High-dose" metronidazole: a preliminary pharmacological study prior to its investigational use in clinical radiotherapy trials.信函：“高剂量”甲硝唑：在临床放射治疗试验中进行研究性使用之前的初步药理学研究。
Br J Radiol. 1974 May;47(557):297-9. doi: 10.1259/0007-1285-47-557-297-c.
4
Hydrogenosome, a cytoplasmic organelle of the anaerobic flagellate Tritrichomonas foetus, and its role in pyruvate metabolism.氢化酶体，一种厌氧鞭毛虫胎儿三毛滴虫的细胞质细胞器，及其在丙酮酸代谢中的作用。
J Biol Chem. 1973 Nov 25;248(22):7724-8.
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Anaerobic bacteriology. Isolation and identification of Bacteroides and Fusobacterium from human sources.厌氧细菌学。从人体样本中分离和鉴定拟杆菌属和梭杆菌属。
Aust J Exp Biol Med Sci. 1974 Dec;52(6):897-908.
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The mode of action of metronidazole in Trichomonas vaginalis and other micro-organisms.甲硝唑在阴道毛滴虫及其他微生物中的作用方式。
Biochem Pharmacol. 1974 May 1;23(9):1421-9. doi: 10.1016/0006-2952(74)90362-1.
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Human studies with "high dose" metronidazole: a non-toxic radiosensitizer of hypoxic cells.“高剂量”甲硝唑的人体研究：一种低氧细胞的无毒放射增敏剂。
Br J Cancer. 1975 Jan;31(1):75-80. doi: 10.1038/bjc.1975.9.
8
An evaluation of metronidazole in the prophylaxis and treatment of anaerobic infections in surgical patients.甲硝唑在外科患者厌氧菌感染预防和治疗中的评估。
J Antimicrob Chemother. 1975 Dec;1(4):393-41. doi: 10.1093/jac/1.4.393.
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Treatment of anaerobic infections with metronidazole.甲硝唑治疗厌氧菌感染
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10
NAD- and NADP-dependent 7alpha-hydroxysteroid dehydrogenases from bacteroides fragilis.脆弱拟杆菌中依赖NAD和NADP的7α-羟基类固醇脱氢酶
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脆弱拟杆菌甲硝唑耐药突变体的分离与特性

Isolation and properties of metronidazole-resistant mutants of Bacteroides fragilis.

作者信息

Britz M L, Wilkinson R G

出版信息

Antimicrob Agents Chemother. 1979 Jul;16(1):19-27. doi: 10.1128/AAC.16.1.19.

DOI:10.1128/AAC.16.1.19
PMID:475371
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC352781/
Abstract

Metronidazole-resistant mutants of Bacteroides fragilis, isolated after mutagenesis, had diminished ability to take up and metabolize the drug. All the metronidazole-resistant strains had depressed levels of pyruvate dehydrogenase compared with parent cultures. Their end products of glucose metabolism also differed from normal B. fragilis products and were consistent with deficiencies in pyruvate dehydrogenase activity.

摘要

经诱变后分离得到的脆弱拟杆菌甲硝唑耐药突变体摄取和代谢该药物的能力有所下降。与亲代培养物相比，所有甲硝唑耐药菌株的丙酮酸脱氢酶水平均降低。它们的葡萄糖代谢终产物也与正常脆弱拟杆菌的产物不同，这与丙酮酸脱氢酶活性缺陷一致。