脆弱拟杆菌甲硝唑耐药突变体的分离与特性
Isolation and properties of metronidazole-resistant mutants of Bacteroides fragilis.
作者信息
Britz M L, Wilkinson R G
出版信息
Antimicrob Agents Chemother. 1979 Jul;16(1):19-27. doi: 10.1128/AAC.16.1.19.
Abstract
Metronidazole-resistant mutants of Bacteroides fragilis, isolated after mutagenesis, had diminished ability to take up and metabolize the drug. All the metronidazole-resistant strains had depressed levels of pyruvate dehydrogenase compared with parent cultures. Their end products of glucose metabolism also differed from normal B. fragilis products and were consistent with deficiencies in pyruvate dehydrogenase activity.
摘要
经诱变后分离得到的脆弱拟杆菌甲硝唑耐药突变体摄取和代谢该药物的能力有所下降。与亲代培养物相比，所有甲硝唑耐药菌株的丙酮酸脱氢酶水平均降低。它们的葡萄糖代谢终产物也与正常脆弱拟杆菌的产物不同，这与丙酮酸脱氢酶活性缺陷一致。
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