甲硝唑治疗厌氧菌感染
Treatment of anaerobic infections with metronidazole.
作者信息
Tally F P, Sutter V L, Finegold S M
出版信息
Antimicrob Agents Chemother. 1975 May;7(5):672-5. doi: 10.1128/AAC.7.5.672.
Abstract
The results of treatment of 10 patients with anaerobic infections with metronidazole are presented. Six patients were cured, three showed initial good response but circumstances required a change to another drug, and one patient did not respond. The unique spectrum of the drug, its pharmacology, and limitations are discussed. The results indicate that further clinical trials to determine the efficacy of metronidazole in the treatment of anerobic infections are indicated.
摘要
本文介绍了10例厌氧菌感染患者使用甲硝唑治疗的结果。6例患者治愈，3例起初反应良好，但因情况需要改用其他药物，1例患者无反应。文中讨论了该药独特的抗菌谱、药理学及局限性。结果表明，有必要进行进一步的临床试验以确定甲硝唑治疗厌氧菌感染的疗效。
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本文引用的文献
1
Absorption and excretion of metronidazole. I. Serum concentration and urinary excretion after oral administration.
Br J Vener Dis. 1961 Dec;37(4):273-5. doi: 10.1136/sti.37.4.273.
2
TREATMENT OF VINCENT'S STOMATITIS WITH METRONIDAZOLE.
Br Med J. 1964 May 2;1(5391):1149-50. doi: 10.1136/bmj.1.5391.1149.
3
[The activity of 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole (R. P. 8823) against experimental Trichomonas vaginalis infections].
Ann Inst Pasteur (Paris). 1959 Feb;96(2):238-41.
4
Metronidazole in human infections with syphilis.
Br J Vener Dis. 1967 Sep;43(3):197-200. doi: 10.1136/sti.43.3.197.
5
Bactericidal activity of five antimicrobial agents against Bacteroides fragilis.
J Infect Dis. 1972 Jul;126(1):104-7. doi: 10.1093/infdis/126.1.104.
6
A six-month controlled evaluation of metronidazole (Flagyl) in chronic alcoholic patients.
Curr Ther Res Clin Exp. 1968 Feb;10(2):82-7.
7
New developments in the therapy of amoebiasis.
Gut. 1970 Nov;11(11):967-9.
8
Toxicity of disulfiram combined with metronidazole.
N Engl J Med. 1969 May 1;280(18):1006-7. doi: 10.1056/NEJM196905012801807.
9
Diagnostic features of clindamycin-associated pseudomembranous colitis.
N Engl J Med. 1974 Apr 11;290(15):841-3. doi: 10.1056/NEJM197404112901508.
10
Resistance of some species of Clostridium to clindamycin.
Antimicrob Agents Chemother. 1973 Jan;3(1):136-7. doi: 10.1128/AAC.3.1.136.
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