洗必泰从新生儿完整皮肤的吸收情况。
Absorption of chlorhexidine from the intact skin of newborn infants.
作者信息
Cowen J, Ellis S H, McAinsh J
出版信息
Arch Dis Child. 1979 May;54(5):379-83. doi: 10.1136/adc.54.5.379.
Abstract
34 newborn infants who had been bathed in a standard manner with Hibiscrub were studied to find out whether it was absorbed percutaneously. Low levels of chlorhexidine were found in the blood of all 10 babies sampled by heel prick, and 5 of 24 from whom venous blood was taken. The detection of chlorhexidine varied greatly with the method and timing of sampling, and no correlation was found between gestational or postnatal age and chlorhexidine levels.
摘要
对34名以标准方式用 Hibiscrub 沐浴的新生儿进行了研究，以确定其是否经皮吸收。在所有10名足跟采血的婴儿以及24名采静脉血的婴儿中的5名婴儿的血液中发现了低水平的氯己定。氯己定的检测结果因采样方法和时间的不同而有很大差异，并且未发现胎龄或出生后年龄与氯己定水平之间存在相关性。
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本文引用的文献
1
DISINFECTION OF HANDS: REMOVAL OF TRANSIENT ORGANISMS.手部消毒：清除暂居菌
Br Med J. 1964 Jul 25;2(5403):230-3. doi: 10.1136/bmj.2.5403.230.
2
METHEMOGLOBINEMIA IN A HOSPITAL NURSERY: A SEARCH FOR CAUSATIVE FACTORS.医院托儿所中的高铁血红蛋白血症：对致病因素的探寻。
JAMA. 1963 Sep 7;185:760-3. doi: 10.1001/jama.1963.03060100040014.
3
The control of staphylococcal skin infections in the nursery.托儿所中葡萄球菌皮肤感染的控制
Can Med Assoc J. 1952 Sep;67(3):247-9.
4
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Am J Dis Child. 1966 Sep;112(3):218-24. doi: 10.1001/archpedi.1966.02090120086008.
5
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J Pediatr. 1969 Aug;75(2):317-25. doi: 10.1016/s0022-3476(69)80407-5.
6
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7
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8
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