新生儿脐带护理中洗必泰的经皮吸收
Percutaneous absorption of chlorhexidine in neonatal cord care.
作者信息
Aggett P J, Cooper L V, Ellis S H, McAinsh J
出版信息
Arch Dis Child. 1981 Nov;56(11):878-80. doi: 10.1136/adc.56.11.878.
Abstract
The percutaneous absorption of chlorhexidine during its routine use in topical antiseptic preparations used in umbilical cord care was investigated by determining plasma chlorhexidine concentrations at ages 5 and 9 days. These showed that percutaneous absorption of chlorhexidine occurred in preterm neonates treated with a 1% solution of chlorhexidine in ethanol, but not in term infants similarly treated, or in preterm infants treated only with a dusting powder containing 1% chlorhexidine and 3% zinc oxide.
摘要
通过测定5日龄和9日龄时血浆洗必泰浓度，研究了洗必泰在脐带护理局部抗菌制剂常规使用过程中的经皮吸收情况。结果表明，用1%洗必泰乙醇溶液治疗的早产儿发生了洗必泰经皮吸收，但接受类似治疗的足月儿或仅使用含1%洗必泰和3%氧化锌扑粉治疗的早产儿未发生洗必泰经皮吸收。
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