Matzel W, Schubert G
Arch Geschwulstforsch. 1979;49(2):146-54.
187 pleural fluids of various etiology are examined with the intention to find hyaluronic acid. The colorimetric method of Morgan-Elson was used for this purpose. The mucopolysaccharid was identified in 34 cases: 18 in 30 cases of diffuse mesotheliomas 1 in 74 cases of secondary tumours of the pleura 8 in 20 cases of tuberculous pleurisy 5 in 37 cases of nonspecific pleurisy 2 in 6 cases of purulent pleursy. A level from more than 212 mg/litre was detected in 10 cases of mesotheliomas only. Such a concentration is consequently the proof for diffuse mesothelioma. The diagnostical improvement in other cases of mesotheliomas resulted from a combination of the following parameters: coagulation of protein by the method of Weltmann, cytological investigation of cellsedimentation and measurement of hyaluronic acid. Our experience with the diagnosis of diffuse mesotheliomas is discussed also in account to the results which are published since 1965 from a scientific team working in Lille, France, reporting the value of detection and measurement on hyaluronic acid in pleural fluids.
对187份不同病因的胸水进行检查以寻找透明质酸。为此采用了摩根 - 埃尔森比色法。在34例中鉴定出黏多糖：30例弥漫性间皮瘤中有18例，74例胸膜继发性肿瘤中有1例，20例结核性胸膜炎中有8例，37例非特异性胸膜炎中有5例，6例脓性胸膜炎中有2例。仅在10例间皮瘤中检测到超过212毫克/升的水平。因此，这样的浓度是弥漫性间皮瘤的证据。其他间皮瘤病例的诊断改进来自以下参数的组合：韦尔特曼法检测蛋白质凝固、细胞沉降的细胞学检查和透明质酸测量。结合自1965年以来法国里尔一个科研团队发表的结果，讨论了我们对弥漫性间皮瘤的诊断经验，该结果报告了胸水中透明质酸检测和测量的价值。
