Mehnert W H, Winkler J, Graffi A
Arch Geschwulstforsch. 1979;49(2):97-105.
Following parenteral application of spores of Clostridium butyricum their intratumoral germination and oncolysis were demonstrated on a variety of mouse transplantation tumors. The germination and propagation of the clostridia was restricted exclusively to the tumor tissue, they could not be demonstrated bacterioscopically in parallelly run normal tissue specimens. The observed differences of germination and lysis rate are due, in part, to tumor host and transplantate-specific properties.
经肠胃外应用丁酸梭菌孢子后,在多种小鼠移植肿瘤上证实了其在肿瘤内的萌发及溶瘤作用。梭菌的萌发与繁殖仅限于肿瘤组织,在同时检测的正常组织标本中未能通过细菌学方法检测到。观察到的萌发率与裂解率差异部分归因于肿瘤宿主及移植瘤的特异性。