Hollins M, Alpern M
J Gen Physiol. 1973 Oct;62(4):430-47. doi: 10.1085/jgp.62.4.430.
Foveal threshold elevation and red-green cone pigment regeneration have been studied in the dark after a wide range of bleaches in normal man with a view to probing the limits of the application of the Dowling-Rushton relation: i.e., the direct proportionality between log threshold elevation and fraction of unregenerated pigment. Cone pigment regeneration (and threshold recovery) is much faster after short bleaches than expected from the kinetics of a simple monomolecular reaction. Recovery is faster after a fixed (short) duration bleach the weaker it is. Except for the first 30 s after relatively weak bleaches and the entire recovery after a very brief (<0.001 s) saturating bright flash which bleaches a little more than 50%, the results are accurately fit by the Dowling-Rushton relation over the entire range tested with only one arbitrary constant (the proportionality factor). Theory predicts too low threshold in comparison with what is obtained, for both of these exceptions
在正常人体中，经过一系列不同程度漂白后，于黑暗环境下研究了中央凹阈值升高和红绿色视锥色素再生情况，旨在探究道林-拉什顿关系的应用限度，即对数阈值升高与未再生色素比例之间的直接比例关系。视锥色素再生（以及阈值恢复）在短时间漂白后比简单单分子反应动力学预期的要快得多。在固定（短）持续时间漂白后，漂白程度越弱，恢复速度越快。除了相对较弱漂白后的前30秒以及极短暂（<0.001秒）饱和明亮闪光（其漂白程度略超过50%）后的整个恢复过程外，在整个测试范围内，结果仅用一个任意常数（比例因子）就能准确地符合道林-拉什顿关系。对于这两种例外情况，理论预测的阈值与实际获得的阈值相比过低。
