Aphidicolin inhibits eukaryotic DNA replication and repair --- implications for involvement of DNA polymerase alpha in both processes.

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作者信息

Berger N A, Kurohara K K, Petzold S J, Sikorski G W

出版信息

Biochem Biophys Res Commun. 1979 Jul 12;89(1):218-25. doi: 10.1016/0006-291x(79)90966-5.

DOI:10.1016/0006-291x(79)90966-5

PMID:475808

Abstract

摘要

相似文献

Aphidicolin inhibits eukaryotic DNA replication and repair --- implications for involvement of DNA polymerase alpha in both processes.

Biochem Biophys Res Commun. 1979 Jul 12;89(1):218-25. doi: 10.1016/0006-291x(79)90966-5.

DNA repair in ultraviolet-irradiated HeLa cells is disrupted by aphidicolin. The inhibition of repair need not imply the absence of repair synthesis.在紫外线照射的海拉细胞中，DNA修复被阿非科林破坏。对修复的抑制并不一定意味着不存在修复合成。

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2',3'-Dideoxythymidine 5'-triphosphate inhibition of DNA replication and ultraviolet-induced DNA repair synthesis in human cells: evidence for involvement of DNA polymerase delta.2',3'-双脱氧胸苷5'-三磷酸对人细胞DNA复制及紫外线诱导的DNA修复合成的抑制作用：DNA聚合酶δ参与的证据

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Involvement of DNA polymerase delta in DNA repair synthesis in human fibroblasts at late times after ultraviolet irradiation.紫外线照射后晚期人成纤维细胞中DNA聚合酶δ参与DNA修复合成。

Biochemistry. 1988 Aug 23;27(17):6379-83. doi: 10.1021/bi00417a028.

The effect of inhibitors of DNA synthesis on DNA repair.DNA合成抑制剂对DNA修复的影响。

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Aphidicolin does not inhibit the repair synthesis of mitotic chromosomes.阿非科林不抑制有丝分裂染色体的修复合成。

Biochem Biophys Res Commun. 1981 Apr 30;99(4):1287-94. doi: 10.1016/0006-291x(81)90759-2.

The effect of aphidicolin in DNA repair on resting and mitogen stimulated human lymphocytes.

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Functional roles of the plant alpha-like and gamma-like DNA polymerases.植物α类和γ类DNA聚合酶的功能作用。

FEBS Lett. 1981 Feb 9;124(1):112-8. doi: 10.1016/0014-5793(81)80064-6.

DNA polymerase delta mediates excision repair in growing cells damaged with ultraviolet radiation.

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Enhancement of ultraviolet-induced unscheduled DNA synthesis in HeLa cell lysate by aphidicolin in vivo.体内阿非科林对紫外线诱导的HeLa细胞裂解物中DNA的非预定合成的增强作用。

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DNA replication is an integral part of the mouse oocyte's reprogramming machinery.DNA 复制是小鼠卵母细胞重编程机制的一个组成部分。

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Dynamic link of DNA demethylation, DNA strand breaks and repair in mouse zygotes.DNA 去甲基化、DNA 链断裂与修复在小鼠受精卵中的动态关联

EMBO J. 2010 Jun 2;29(11):1877-88. doi: 10.1038/emboj.2010.80. Epub 2010 May 4.

Mismatch Repair proteins are recruited to replicating DNA through interaction with Proliferating Cell Nuclear Antigen (PCNA).错配修复蛋白通过与增殖细胞核抗原（PCNA）相互作用被招募到正在复制的DNA上。

Nucleic Acids Res. 2008 Jan;36(1):67-75. doi: 10.1093/nar/gkm943. Epub 2007 Nov 5.

Effects of DNA replication inhibitors on UV excision repair in synchronised human cells.DNA复制抑制剂对同步化人类细胞紫外线切除修复的影响。

Nucleic Acids Res. 1982 Sep 11;10(17):5357-68. doi: 10.1093/nar/10.17.5357.

The effect of aphidicolin on the rate of DNA replication and unscheduled DNA synthesis of Bloom syndrome and normal fibroblasts.阿非科林对布卢姆综合征和成纤维细胞DNA复制速率及DNA修复合成的影响。

Hum Genet. 1982;60(4):357-9. doi: 10.1007/BF00569218.

Aphidicolin does not inhibit DNA repair synthesis in ultraviolet-irradiated HeLa cells. A radioautographic study.阿非科林不抑制紫外线照射的HeLa细胞中的DNA修复合成。一项放射自显影研究。

Biochem J. 1981 Nov 1;199(2):453-5. doi: 10.1042/bj1990453.

Inhibitors of repair DNA synthesis.DNA修复合成抑制剂。

Nucleic Acids Res. 1982 Feb 25;10(4):1203-13. doi: 10.1093/nar/10.4.1203.

Mammalian mutator mutant with an aphidicolin-resistant DNA polymerase alpha.具有阿非科林抗性DNA聚合酶α的哺乳动物突变体。

Proc Natl Acad Sci U S A. 1983 Feb;80(3):797-801. doi: 10.1073/pnas.80.3.797.

Gene expression of human DNA polymerase alpha during cell proliferation and the cell cycle.细胞增殖和细胞周期过程中人类DNA聚合酶α的基因表达

Mol Cell Biol. 1988 Nov;8(11):5016-25. doi: 10.1128/mcb.8.11.5016-5025.1988.

Arabinofuranosyl nucleosides induce common fragile sites.阿拉伯呋喃糖基核苷诱导常见脆性位点。

Hum Genet. 1988 Jun;79(2):157-62. doi: 10.1007/BF00280556.

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