Collins A
Biochim Biophys Acta. 1983 Dec 22;741(3):341-7. doi: 10.1016/0167-4781(83)90154-9.
Aphidicolin, a potent and specific inhibitor of eukaryotic DNA polymerase alpha, has been reported to inhibit repair DNA synthesis in ultraviolet-irradiated, normal human fibroblasts but not in HeLa cells. By the use of assays for repair other than the measurement of repair synthesis, it is shown here that repair in HeLa cells is in fact susceptible to aphidicolin. Severe inhibition of DNA repair, with failure of individual repair events to be completed, and a smaller number of lesions removed, can occur even though repair synthesis continues.
放线菌素，一种有效的、特异性的真核生物DNA聚合酶α抑制剂，据报道可抑制紫外线照射的正常人成纤维细胞中的修复性DNA合成，但对HeLa细胞无效。通过使用除测量修复合成之外的修复检测方法，本文表明HeLa细胞中的修复实际上对放线菌素敏感。即使修复合成继续进行，也可能发生DNA修复的严重抑制，个别修复事件无法完成，并且去除的损伤数量减少。
