Hardt N, Pedrali-Noy G, Focher F, Spadari S
Biochem J. 1981 Nov 1;199(2):453-5. doi: 10.1042/bj1990453.
A radioautographic examination of nuclear DNA synthesis in unirradiated and u.v.-irradiated HeLa cells, in the presence and in the absence of aphidicolin, showed that aphidicolin inhibits nuclear DNA replication and has no detectable effect on DNA repair synthesis. Although the results establish that in u.v.-irradiated HeLa cells most of the DNA repair synthesis is not due to DNA polymerase alpha, they do not preclude a significant role for this enzyme in DNA repair processes.
在有无阿非迪霉素的情况下，对未受辐射和紫外线辐射的海拉细胞的核DNA合成进行放射自显影检查，结果表明阿非迪霉素抑制核DNA复制，对DNA修复合成没有可检测到的影响。尽管结果表明在紫外线辐射的海拉细胞中，大部分DNA修复合成并非由DNA聚合酶α所致，但并不排除该酶在DNA修复过程中起重要作用。
