Leucocytes and Trichinella spiralis. 3. Importance of heat labile and heat stable substances in peritoneal exudate fluid for cell adherence reactions to infective larvae.

The investigation of cell adherence reactions (CAR) to infective larvae in peritoneal exudates obtained from rats and mice has shown that the adherence of leucocytes is almost entirely dependent upon factors present in the peritoneal exudate fluids (PEF). The heat-labile factor is primarily responsible for influencing adherences to worms in PEF obtained from non-infected animals. In the PEF obtained from infected animals, a heat stable factor is present, in addition. This heat stable factor can be adsorbed to surfaces of worms and was found up to at least 9 months after infection in rats. The heat stable factor can be absorbed from the PEF with infective larvae.