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淋巴因子对针对无关抗原的迟发型超敏反应发展的影响。

The effect of lymphokines on the development of delayed hypersensitivity to an unrelated antigen.

作者信息

Krejcí J, Pekàrek J, Svejcar J, Johanovskỳ J

出版信息

Immunology. 1973 Nov;25(5):875-9.

PMID:4761637
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1423033/
Abstract

The development of delayed hypersensitivity to sheep red cells in rabbits was assessed by measuring the inhibition of migration of cells from spleen fragments in the presence of sheep red cell antigen. Supernatants containing migration inhibition factor were prepared by incubating lymph node cells from rabbits immunized with Freund's complete adjuvant with PPD. Sheep red cells injected together with these supernatants intravenously gave rise to delayed hypersensitivity. In contrast the injection of sheep red cells alone or with control supernatants did not give rise to delayed hypersensitivity.

摘要

通过测量在绵羊红细胞抗原存在的情况下脾碎片细胞迁移的抑制情况，评估家兔对绵羊红细胞迟发型超敏反应的发展。用弗氏完全佐剂免疫的家兔的淋巴结细胞与结核菌素纯蛋白衍生物一起孵育，制备含有迁移抑制因子的上清液。将绵羊红细胞与这些上清液一起静脉注射可引起迟发型超敏反应。相比之下，单独注射绵羊红细胞或与对照上清液一起注射则不会引起迟发型超敏反应。

相似文献

1
The effect of lymphokines on the development of delayed hypersensitivity to an unrelated antigen.淋巴因子对针对无关抗原的迟发型超敏反应发展的影响。
Immunology. 1973 Nov;25(5):875-9.
2
Immunogenicity of spermatozoa.精子的免疫原性。
Invest Urol. 1974 Nov;12(3):193-9.
3
Survey of recent studies on mechanism and significance of delayed (cellular)-type hypersensitivity.迟发型（细胞）型超敏反应机制及意义的近期研究综述
Ann Immunol Hung. 1972;16(0):191-8.
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Interaction between 'sensitized lymphocytes' and antigen in vitro. 3. Release of soluble mediators by particulate antigen.“致敏淋巴细胞”与抗原在体外的相互作用。3. 颗粒性抗原释放可溶性介质
Immunology. 1972 Jan;22(1):25-37.
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[Delayed hypersensitivity in vitro. 1. Inhibition of the antigen against migration of cells in the spleen and lymph nodes of guinea pigs sensitized to delayed-type hypersensitivity].[体外迟发型超敏反应。1. 针对迟发型超敏反应致敏豚鼠脾脏和淋巴结中细胞迁移的抗原抑制作用]
Igaku To Seibutsugaku. 1968 Oct 10;77(4):123-9.
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Mediators of cellular hypersensitivity and immunity including immunologically specific factors.细胞超敏反应和免疫的介质，包括免疫特异性因子。
Adv Exp Med Biol. 1973;29(0):619-26. doi: 10.1007/978-1-4615-9017-0_89.
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Changes in lymphocyte circulation after administration of antigen.抗原给药后淋巴细胞循环的变化。
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[Delayed type hypersensitivity in vitro. 2. Inhibition of the antigen against migration of cells in vitro capable of transferring tuberculin hypersensitivity].[体外迟发型超敏反应。2. 抗原对体外能够传递结核菌素超敏反应的细胞迁移的抑制作用]
Igaku To Seibutsugaku. 1968 Oct 10;77(4):131-7.
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[Specific inhibition of lymphocytes, proliferating in response to an antigen, in mouse lymph nodes containing the same antigen].[在含有相同抗原的小鼠淋巴结中，对因抗原而增殖的淋巴细胞的特异性抑制作用]
Biull Eksp Biol Med. 1973 Oct;75(10):74-7.

引用本文的文献

1
Hypersensitivity reactions in the small intestine. 2. Effects of allograft rejection on mucosal architecture and lymphoid cell infiltrate.小肠中的超敏反应。2. 同种异体移植排斥对黏膜结构和淋巴细胞浸润的影响。
Gut. 1976 Feb;17(2):81-91. doi: 10.1136/gut.17.2.81.

本文引用的文献

1
DELAYED HYPERSENSITIVITY IN VITRO. I. THE SPECIFICITY OF INHIBITION OF CELL MIGRATION BY ANTIGENS.体外迟发型超敏反应。I. 抗原对细胞迁移抑制作用的特异性。
J Immunol. 1964 Aug;93:264-73.
2
Mechanism of a reaction in vitro associated with delayed-type hypersensitivity.体外与迟发型超敏反应相关的反应机制。
Science. 1966 Jul 1;153(3731):80-2. doi: 10.1126/science.153.3731.80.
3
In vitro correlates of transplantation immunity: the release of substances by immune lymphocytes confronted with specific antigens.移植免疫的体外相关因素：免疫淋巴细胞在接触特定抗原时释放物质。
Surgery. 1969 Jul;66(1):51-7.
4
Studies on production of biologically active substances which inhibit cell migration in supernatants and extracts of hypersensitive lymphoid cells incubated with specific antigen in vitro.关于体外培养的超敏淋巴细胞与特异性抗原孵育后，其培养上清液和提取物中抑制细胞迁移的生物活性物质产生的研究。
Immunology. 1968 Jul;15(1):1-11.
5
Immunological adjuvants and the mechanism of cell cooperation.免疫佐剂与细胞合作机制
J Exp Med. 1972 Jul 1;136(1):185-90. doi: 10.1084/jem.136.1.185.
6
Macrophage-bound antigens. I. Induction of delayed hypersensitivity and priming for production of serum antibodies in guinea pigs.巨噬细胞结合抗原。I. 豚鼠迟发型超敏反应的诱导及血清抗体产生的致敏作用。
J Immunol. 1972 Aug;109(2):244-54.
7
Cells involved in cell-mediated and transplantation immunity in the rabbit. IV. The organ localization of the cells capable of migrating in vitro. Inhibition of migration by immunizing antigen.家兔中参与细胞介导免疫和移植免疫的细胞。IV. 体外可迁移细胞的器官定位。免疫抗原对迁移的抑制作用。
Cell Immunol. 1972 Nov;5(3):377-91. doi: 10.1016/0008-8749(72)90064-0.
8
Preferential induction of cell-mediated immunity by chemically modified sheep erythrocytes.化学修饰的绵羊红细胞对细胞介导免疫的优先诱导作用。
Eur J Immunol. 1972 Apr;2(2):143-51. doi: 10.1002/eji.1830020210.
9
Role of mediators of cellular hypersensitivity in the stimulation of the antibody formation to unrelated antigen.
Cell Immunol. 1973 May;7(2):322-7. doi: 10.1016/0008-8749(73)90254-2.
10
Demonstration of migration inhibiting substances in sera of guinea pigs with delayed type hypersensitivity to ovalbumin influenced with systemic antigen administration.对经全身抗原给药影响的、对卵清蛋白具有迟发型超敏反应的豚鼠血清中迁移抑制物质的证明。
Z Immunitatsforsch Allerg Klin Immunol. 1968 Aug-Sep;136(3):259-67.