环磷酰胺与丙卡巴肼对小鼠抗体产生作用的比较研究。
A comparative study of the action of cyclophosphamide and procarbazine on the antibody production in mice.
作者信息
Liske R
出版信息
Clin Exp Immunol. 1973 Oct;15(2):271-80.
The effect of procarbazine and cyclophosphamide on the formation of antibodies to sheep red blood cells in mice is investigated. Cyclophosphamide was found to have the best immunosuppressive effect when given after antigen; recovery from drug treatment was relatively fast; under experimental conditions that favour cyclophosphamide action (antigen prior to drug) IgM formation was found to be depressed and prolonged; IgG formation was markedly depressed or altogether missing. Procarbazine was found to act best when given prior to antigen; recovery was slow; under experimental conditions that favour procarbazine action (drug prior to antigen) the induction period was prolonged. IgM titres were slightly and IgG titres markedly depressed. Under all conditions tested procarbazine had little effect on the onset of IgG production.
研究了丙卡巴肼和环磷酰胺对小鼠抗绵羊红细胞抗体形成的影响。发现环磷酰胺在抗原给药后使用时具有最佳的免疫抑制效果；药物治疗后的恢复相对较快；在有利于环磷酰胺作用的实验条件下（抗原在药物之前），发现IgM的形成受到抑制且时间延长；IgG的形成明显受到抑制或完全缺失。发现丙卡巴肼在抗原给药之前使用时效果最佳；恢复缓慢；在有利于丙卡巴肼作用的实验条件下（药物在抗原之前），诱导期延长。IgM滴度略有下降，IgG滴度明显下降。在所有测试条件下，丙卡巴肼对IgG产生的起始几乎没有影响。
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