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A comparative study of the action of cyclophosphamide and procarbazine on the antibody production in mice.环磷酰胺与丙卡巴肼对小鼠抗体产生作用的比较研究。
Clin Exp Immunol. 1973 Oct;15(2):271-80.
2
[The effect of cyclophosphane on gamma M- and gamma G-antibody production].[环磷酰胺对γM和γG抗体产生的影响]
Vopr Onkol. 1970;16(10):54-8.
3
[Immunological response with aging].[衰老过程中的免疫反应]
Immun Infekt. 1973 Oct;1(1):26-32.
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The effect of cyclophosphamide on the ontogeny of the humoral immune response in chickens.环磷酰胺对鸡体液免疫反应个体发育的影响。
J Immunol. 1970 Sep;105(3):614-9.
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Enhancement of antibody production after treatment with actinomycin-D: interrelationships between 7S and 19S antibody.放线菌素-D 治疗后抗体产生的增强：7S 与 19S 抗体之间的相互关系
Immunology. 1968 Feb;14(2):213-24.
6
[Effect of prednisolone on the production of circulating 19S and 7S antibodies].
Farmakol Toksikol. 1971 May-Jun;34(3):313-6.
7
The effect of chronic daily cyclophosphamide administration on established antibody responses.每日长期给予环磷酰胺对已建立的抗体反应的影响。
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8
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Z Immunitatsforsch Exp Klin Immunol. 1974 May;147(1):69-78.
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3
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Mycopathologia. 1977 Feb 18;60(2):79-85. doi: 10.1007/BF00490376.
4
Suppressive effect of cyclophosphamide on the T-cell system in chickens.环磷酰胺对鸡T细胞系统的抑制作用。
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Genetically determined resistance to infection by hepatotropic influenza A virus in mice: effect of immunosuppression.小鼠对嗜肝甲型流感病毒感染的遗传决定抗性：免疫抑制的影响。
Infect Immun. 1976 Mar;13(3):844-54. doi: 10.1128/iai.13.3.844-854.1976.

本文引用的文献

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INHIBITION OF HEMAGGLUTININ SYNTHESIS BY CYTOXAN.环磷酰胺对血凝素合成的抑制作用
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2
EFFECT OF 6-MERCAPTOPURINE (6-MP) ON DIFFERENT CLASSES OF ANTIBODY.6-巯基嘌呤（6-MP）对不同类别抗体的作用
J Exp Med. 1965 Aug 1;122(2):263-75. doi: 10.1084/jem.122.2.263.
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[SCREENING OF ANTIRHEUMATICS ON A TUBERCULIN REACTION MODEL].[抗风湿药在结核菌素反应模型上的筛选]
Helv Physiol Pharmacol Acta. 1964;22:92-109.
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INHIBITION OF 19S ANTIBODY SYNTHESIS BY 7S ANTIBODY.7S抗体对19S抗体合成的抑制作用。
Science. 1964 Jul 24;145(3630):395-7. doi: 10.1126/science.145.3630.395.
5
THE FORMATION AND PROPERTIES OF POLIOVIRUS-NEUTRALIZING ANTIBODY. II. 19S AND 7S ANTIBODY FORMATION: DIFFERENCES IN ANTIGEN DOSE REQUIREMENT FOR SUSTAINED SYNTHESIS, ANAMNESIS, AND SENSITIVITY TO X-IRRADIATION.脊髓灰质炎病毒中和抗体的形成与特性。II. 19S和7S抗体的形成：持续合成、回忆反应及对X射线照射敏感性方面抗原剂量需求的差异
J Exp Med. 1964 Jan 1;119(1):21-39. doi: 10.1084/jem.119.1.21.
6
[EXTENDED SURVIVAL OF SKIN HOMOGRAFTS IN MICE BY A METHYLHYDRAZINE DERIVATIVE].[一种甲基肼衍生物延长小鼠皮肤同种异体移植的存活时间]
Experientia. 1963 Oct 15;19:546-7. doi: 10.1007/BF02150908.
7
Suppression of the immunological reaction by methylhydrazines, a new class of antitumour agents.新型抗肿瘤药甲基肼对免疫反应的抑制作用
Experientia. 1963 Jun 15;19:304-5. doi: 10.1007/BF02150420.
8
19S and 17S antibody production in the cyclophosphamide- or methotrexate-treated rat.环磷酰胺或甲氨蝶呤处理的大鼠体内19S和17S抗体的产生
Nature. 1966 Feb 5;209(5023):622-4. doi: 10.1038/209622a0.
9
Symposium on immunosuppressive drugs. Immunosuppressive drugs. II.免疫抑制药物研讨会。免疫抑制药物。第二部分。
Fed Proc. 1967 May-Jun;26(3):914-7.
10
Immunosuppressive effects of cytosine arabinoside and methotrexate in man.阿糖胞苷和甲氨蝶呤对人体的免疫抑制作用。
Ann Intern Med. 1969 Mar;70(3):535-47. doi: 10.7326/0003-4819-70-3-535.

环磷酰胺与丙卡巴肼对小鼠抗体产生作用的比较研究。

A comparative study of the action of cyclophosphamide and procarbazine on the antibody production in mice.

作者信息

Liske R

出版信息

Clin Exp Immunol. 1973 Oct;15(2):271-80.

PMID:4762019
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1553883/
Abstract

The effect of procarbazine and cyclophosphamide on the formation of antibodies to sheep red blood cells in mice is investigated. Cyclophosphamide was found to have the best immunosuppressive effect when given after antigen; recovery from drug treatment was relatively fast; under experimental conditions that favour cyclophosphamide action (antigen prior to drug) IgM formation was found to be depressed and prolonged; IgG formation was markedly depressed or altogether missing. Procarbazine was found to act best when given prior to antigen; recovery was slow; under experimental conditions that favour procarbazine action (drug prior to antigen) the induction period was prolonged. IgM titres were slightly and IgG titres markedly depressed. Under all conditions tested procarbazine had little effect on the onset of IgG production.

摘要

研究了丙卡巴肼和环磷酰胺对小鼠抗绵羊红细胞抗体形成的影响。发现环磷酰胺在抗原给药后使用时具有最佳的免疫抑制效果；药物治疗后的恢复相对较快；在有利于环磷酰胺作用的实验条件下（抗原在药物之前），发现IgM的形成受到抑制且时间延长；IgG的形成明显受到抑制或完全缺失。发现丙卡巴肼在抗原给药之前使用时效果最佳；恢复缓慢；在有利于丙卡巴肼作用的实验条件下（药物在抗原之前），诱导期延长。IgM滴度略有下降，IgG滴度明显下降。在所有测试条件下，丙卡巴肼对IgG产生的起始几乎没有影响。