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The possible role of metabolites in therapeutic response to chlorpromazine treatment.

作者信息

Sakalis G, Chan T L, Gershon S, Park S

出版信息

Psychopharmacologia. 1973 Sep 28;32(3):279-84. doi: 10.1007/BF00422150.

DOI:10.1007/BF00422150
PMID:4762235
Abstract
摘要

相似文献

1
The possible role of metabolites in therapeutic response to chlorpromazine treatment.代谢物在氯丙嗪治疗反应中的可能作用。
Psychopharmacologia. 1973 Sep 28;32(3):279-84. doi: 10.1007/BF00422150.
2
Quantitation of chlorpromazine and its metabolites in human plasma and urine by direct spectrodensitometry of thin-layer chromatograms.通过薄层色谱图直接光密度测定法定量测定人血浆和尿液中的氯丙嗪及其代谢物。
Adv Biochem Psychopharmacol. 1974;9(0):323-33.
3
Chlorpromazine metabolite pattern in psychotic patients.精神病患者中氯丙嗪的代谢物模式。
J Psychiatr Res. 1967 Dec;5(4):327-33. doi: 10.1016/0022-3956(67)90021-0.
4
Qualitative and quantitative report on chlorpromazine and metabolites in plasma, erythrocytes and erythrocyte washings from chronically medicated schizophrenic patients.
J Med. 1972;3(2):109-20.
5
Response in chronic schizophrenia correlated with chlorpromazine, 7-OH-chlorpromazine and chlorpromazine sulfoxide levels.慢性精神分裂症的反应与氯丙嗪、7-羟基氯丙嗪和氯丙嗪亚砜水平相关。
Eur Neuropsychopharmacol. 1996 May;6(2):85-91. doi: 10.1016/0924-977x(95)00047-s.
6
Chlorpromazine metabolism. V. Disposition of free and conjugated metabolites in blood fractions of schizophrenic patients.氯丙嗪代谢。V. 精神分裂症患者血液组分中游离及结合代谢物的分布
J Pharm Sci. 1972 Nov;61(11):1753-7. doi: 10.1002/jps.2600611112.
7
Thin-layer chromatography of chlorpromazine metabolites. Attempt to identify each of the metabolites appearing in blood, urine and feces of chronically medicated schizophrenics.氯丙嗪代谢物的薄层色谱法。试图鉴定长期用药的精神分裂症患者血液、尿液和粪便中出现的每种代谢物。
J Chromatogr. 1973 Jan 17;75(2):277-93. doi: 10.1016/s0021-9673(00)85556-9.
8
The assay of chlorpromazine and metabolites in blood, urine, and other tissues.血液、尿液及其他组织中氯丙嗪及其代谢物的测定。
CRC Crit Rev Clin Lab Sci. 1971 Sep;2(3):347-91. doi: 10.3109/10408367109151312.
9
[Level of free and bound chlorpromazine fractions in the blood and urine during chlorpromazine treatment].[氯丙嗪治疗期间血液及尿液中游离和结合氯丙嗪组分的水平]
Psychiatr Pol. 1970 Jul-Aug;4(4):435-42.
10
[Clinical significance of pattern of blood chlorpromazine and its metabolite levels and prediction of response to chlorpromazine treatment--studies on the rational pharmacotherapy in schizophrenics (author's transl)].氯丙嗪及其代谢产物血药浓度模式的临床意义及对氯丙嗪治疗反应的预测——精神分裂症合理药物治疗的研究（作者译）
Seishin Shinkeigaku Zasshi. 1978 Jul;80(7):405-24.

引用本文的文献

1
The relationship of plasma chlorpromazine to its 7-hydroxy and sulphoxide metabolites in a large population of chronic schizophrenics.大样本慢性精神分裂症患者的血浆氯丙嗪与其 7-羟基代谢物和亚砜代谢物的关系。
Br J Clin Pharmacol. 1974 Oct;1(5):425-30. doi: 10.1111/j.1365-2125.1974.tb00281.x.
2
Predictive indices for chlorpromazine therapy in schizophrenics.精神分裂症患者氯丙嗪治疗的预测指标。
Br J Clin Pharmacol. 1982 Aug;14(2):273-7. doi: 10.1111/j.1365-2125.1982.tb01973.x.
3
Phase I metabolism of imipramine by microsomes of small intestine in comparison with metabolism by liver microsomes.

本文引用的文献

1
Chlorpromazine metabolism in humans. Part I. Quantitation of chlorpromazine and its metabolites in human plasma and urine by direct scan spectrodensitometry.氯丙嗪在人体内的代谢。第一部分。通过直接扫描光密度法对人血浆和尿液中的氯丙嗪及其代谢物进行定量分析。
Mikrochim Acta. 1973(3):435-52.
2
A comparative pharmacological study of a series of monohydroxylated and methoxylated chlorpromazine derivatives.一系列单羟基化和甲氧基化氯丙嗪衍生物的比较药理学研究。
Life Sci. 1965 Dec;4(24):2425-38. doi: 10.1016/0024-3205(65)90298-5.
3
Determination of nanogram quantities of chlorpromazine and some of its metabolites in plasma using gas-liquid chromatography with an electron capture detector.
与肝脏微粒体代谢相比，小肠微粒体对丙咪嗪的I相代谢。
Naunyn Schmiedebergs Arch Pharmacol. 1983 Jun;323(2):176-82. doi: 10.1007/BF00634268.
4
The presence of 7-hydroxychlorpromazine in CSF of chloropromazine-treated patients.
Psychopharmacology (Berl). 1982;77(4):376-8. doi: 10.1007/BF00432774.
5
Fluphenazine pharmacokinetics and therapeutic response.氟奋乃静的药代动力学与治疗反应。
Psychopharmacology (Berl). 1981;73(3):205-10. doi: 10.1007/BF00422403.
6
Concentrations of chlorpromazine and two of its active metabolites in plasma and cerebrospinal fluid of psychotic patients treated with fixed drug doses.接受固定药物剂量治疗的精神病患者血浆和脑脊液中氯丙嗪及其两种活性代谢物的浓度。
Psychopharmacology (Berl). 1981;73(1):55-62. doi: 10.1007/BF00431102.
7
Serum neuroleptic concentrations and clinical response: a radioreceptor assay investigation of acutely psychotic patients.血清抗精神病药物浓度与临床反应：急性精神病患者的放射受体分析研究
Psychopharmacology (Berl). 1984;82(3):194-8. doi: 10.1007/BF00427772.
8
Dopamine, serotonin and alpha-adrenergic receptor blocking activities in serum and their relationships to prolactin level in schizophrenic patients receiving long-term chlorpromazine treatment.长期接受氯丙嗪治疗的精神分裂症患者血清中的多巴胺、5-羟色胺及α-肾上腺素能受体阻断活性及其与催乳素水平的关系。
Psychopharmacology (Berl). 1983;79(2-3):266-70. doi: 10.1007/BF00427825.
9
The sulfoxidation of fluphenazine in schizophrenic patients maintained on fluphenazine decanoate.癸酸氟奋乃静维持治疗的精神分裂症患者中氟奋乃静的硫氧化作用
Psychopharmacology (Berl). 1987;93(3):369-73. doi: 10.1007/BF00187259.
10
Inhibition of 5-hydroxytryptamine-induced human blood platelet aggregation by chlorpromazine and its metabolites.氯丙嗪及其代谢产物对5-羟色胺诱导的人血小板聚集的抑制作用。
Br J Pharmacol. 1975 Jan;53(1):121-5. doi: 10.1111/j.1476-5381.1975.tb07338.x.
使用带有电子捕获检测器的气液色谱法测定血浆中纳克量的氯丙嗪及其一些代谢物。
Anal Chem. 1968 Jul;40(8):1251-5. doi: 10.1021/ac60264a031.
4
A new method for measuring minute amounts of chlorpromazine and some of its metabolites in plasma.一种测量血浆中微量氯丙嗪及其某些代谢物的新方法。
Agressologie. 1968 Jan-Feb;9(1):103-7.
5
Effect of various chlorpromazine metabolites on amphetamine-induced stereotyped behaviour in the rat.多种氯丙嗪代谢产物对大鼠苯丙胺诱导的刻板行为的影响。
Eur J Pharmacol. 1972 Feb;17(2):283-6. doi: 10.1016/0014-2999(72)90171-9.
6
Appearance of monohydroxylated chlorpromazine metabolites in the central nervous system.单羟基化氯丙嗪代谢物在中枢神经系统中的出现。
Life Sci I. 1971 Jun 15;10(12):679-84. doi: 10.1016/0024-3205(71)90010-5.
7
Proceedings: Clinical pharmacology of chlorpromazine.会议论文：氯丙嗪的临床药理学
Br J Pharmacol. 1972 Feb;44(2):370P-371P.