Chetty M, Pillay V L, Moodley S V, Miller R
Department of Pharmacy, Wits University Medical School, Parktown, South Africa.
Eur Neuropsychopharmacol. 1996 May;6(2):85-91. doi: 10.1016/0924-977x(95)00047-s.
The relationship between chlorpromazine, six of its metabolites and therapeutic response in chronic schizophrenic patients was investigated in this study. Logistic regression revealed no correlation between therapeutic response and four metabolites viz. Nor1 chlorpromazine, Nor2 chlorpromazine, chlorpromazine-N-oxide and Nor2 chlorpromazine sulfoxide. A good correlation was seen between CPZ (P = 0.036), 7-hydroxychlorpromazine (P = 0.004), chlorpromazine sulfoxide (P = 0.002) and therapeutic response. Good therapeutic response was correlated to high levels of chlorpromazine and its 7-hydroxy metabolite while high levels of the sulfoxide metabolite appeared to have a negative effect on therapeutic response. Poor responders who had high levels of chlorpromazine also had high levels of the sulfoxide metabolite. This suggests that the difference in response may lie in the difference in the metabolism of the drug.
本研究调查了氯丙嗪及其六种代谢物与慢性精神分裂症患者治疗反应之间的关系。逻辑回归显示，治疗反应与四种代谢物即去甲氯丙嗪、去甲氯丙嗪、氯丙嗪 - N - 氧化物和去甲氯丙嗪亚砜之间无相关性。氯丙嗪（P = 0.036）、7 - 羟基氯丙嗪（P = 0.004）、氯丙嗪亚砜（P = 0.002）与治疗反应之间存在良好的相关性。良好的治疗反应与高水平的氯丙嗪及其7 - 羟基代谢物相关，而高水平的亚砜代谢物似乎对治疗反应有负面影响。氯丙嗪水平高的低反应者其亚砜代谢物水平也高。这表明反应差异可能在于药物代谢的差异。
