精神分裂症患者氯丙嗪治疗的预测指标。
Predictive indices for chlorpromazine therapy in schizophrenics.
作者信息
Dixon P A, Oforah E, Makanjuola R
出版信息
Br J Clin Pharmacol. 1982 Aug;14(2):273-7. doi: 10.1111/j.1365-2125.1982.tb01973.x.
Abstract
1 Response to chlorpromazine therapy was studied in 24 schizophrenics and 75% reduction in Brief Psychiatric Rating scale (BPRS) within 4 weeks of treatment was taken to indicate good response. 2 Test oral dose of CPZ (200 mg) was administered and serial blood samples and total urine excreted in 6 h were taken for analyses of CPZ and its metabolites. 3 Area under the plasma time curve (AUC) showed an inverted U-shaped relationship with % reduction in BPRS. 4 Three groups of patients were identified, responders, l- and h-group non-responders. 5 l- and h-groups respond on further treatment with haloperidol (30 mg daily) and ECT respectively. 6 Responders showed threshold metabolic molar fraction MMFHO-CPZ greater than or equal to 3.0 x 10(-5) and MMFHO-CPZ/MMFCPZ-SO greater than 1.
摘要
- 对24名精神分裂症患者的氯丙嗪治疗反应进行了研究，治疗4周内简明精神病评定量表（BPRS）评分降低75%被视为反应良好。2. 给予200毫克的氯丙嗪口服试验剂量，并采集连续血样以及6小时内的总尿液，用于分析氯丙嗪及其代谢产物。3. 血浆时间曲线下面积（AUC）与BPRS评分降低百分比呈倒U形关系。4. 确定了三组患者，反应者、低反应组和高反应组无反应者。5. 低反应组和高反应组分别在进一步使用氟哌啶醇（每日30毫克）和电休克治疗后出现反应。6. 反应者的代谢摩尔分数阈值MMFHO-CPZ大于或等于3.0×10⁻⁵，且MMFHO-CPZ/MMFCPZ-SO大于1。
相似文献
1
Predictive indices for chlorpromazine therapy in schizophrenics.精神分裂症患者氯丙嗪治疗的预测指标。
Br J Clin Pharmacol. 1982 Aug;14(2):273-7. doi: 10.1111/j.1365-2125.1982.tb01973.x.
2
Prediction of response to chlorpromazine treatment in schizophrenics.精神分裂症患者对氯丙嗪治疗反应的预测。
Psychopharmacologia. 1975 Oct 31;44(2):195-203. doi: 10.1007/BF00421010.
3
Levomepromazine versus chlorpromazine in treatment-resistant schizophrenia: a double-blind randomized trial.左美丙嗪与氯丙嗪治疗难治性精神分裂症的双盲随机试验。
J Psychiatry Neurosci. 2006 Jul;31(4):271-9.
4
Total and free plasma neuroleptic levels in schizophrenic patients.精神分裂症患者血浆中抗精神病药物的总含量及游离含量
Psychiatry Res. 1984 Dec;13(4):285-93. doi: 10.1016/0165-1781(84)90076-3.
5
Effectiveness of Electroconvulsive Therapy and Associated Cognitive Change in Schizophrenia: A Naturalistic, Comparative Study of Treating Schizophrenia With Electroconvulsive Therapy.电休克治疗对精神分裂症的疗效及相关认知变化：一项电休克治疗精神分裂症的自然对照研究
J ECT. 2017 Dec;33(4):272-277. doi: 10.1097/YCT.0000000000000422.
6
Effects of trihexyphenidyl on plasma chlorpromazine in young schizophrenics.苯海索对年轻精神分裂症患者血浆中氯丙嗪的影响。
Can J Psychiatry. 1990 Oct;35(7):604-7. doi: 10.1177/070674379003500708.
7
Promazine. A major plasma metabolite of chlorpromazine in a population of chronic schizophrenics.丙嗪。慢性精神分裂症患者群体中氯丙嗪的主要血浆代谢物。
Drug Metab Dispos. 1986 Mar-Apr;14(2):263-6.
8
Prediction of drug responses in schizophrenia: a method using a test dose of chlorpromazine.精神分裂症药物反应的预测：一种使用氯丙嗪试验剂量的方法。
Psychiatry Clin Neurosci. 1997 Aug;51(4):217-22. doi: 10.1111/j.1440-1819.1997.tb02586.x.
9
Prediction of response to and actual outcome of chlorpromazine treatment in schizophrenic patients.精神分裂症患者氯丙嗪治疗反应及实际疗效的预测
Arch Gen Psychiatry. 1980 Sep;37(9):1057-62. doi: 10.1001/archpsyc.1980.01780220095011.
10
Quetiapine : A Review of its Use in Schizophrenia.喹硫平：在精神分裂症中的应用评价。
CNS Drugs. 1998 Apr;9(4):325-40. doi: 10.2165/00023210-199809040-00007.
本文引用的文献
1
Prediction of response to and actual outcome of chlorpromazine treatment in schizophrenic patients.精神分裂症患者氯丙嗪治疗反应及实际疗效的预测
Arch Gen Psychiatry. 1980 Sep;37(9):1057-62. doi: 10.1001/archpsyc.1980.01780220095011.
2
Concentrations of chlorpromazine and two of its active metabolites in plasma and cerebrospinal fluid of psychotic patients treated with fixed drug doses.接受固定药物剂量治疗的精神病患者血浆和脑脊液中氯丙嗪及其两种活性代谢物的浓度。
Psychopharmacology (Berl). 1981;73(1):55-62. doi: 10.1007/BF00431102.
3
Dopamine receptors, neuroleptics, and schizophrenia.多巴胺受体、抗精神病药物与精神分裂症
Am J Psychiatry. 1981 Apr;138(4):460-4. doi: 10.1176/ajp.138.4.460.
4
ECT for schizophrenia.精神分裂症的电休克治疗
Lancet. 1980 Jun 28;1(8183):1380-2. doi: 10.1016/s0140-6736(80)92653-7.
5
Chlorpromazine plasma levels and effects.氯丙嗪的血浆水平及效应。
Arch Gen Psychiatry. 1970 Apr;22(4):289-96. doi: 10.1001/archpsyc.1970.01740280001001.
6
Chlorpromazine and dopamine: conformational similarities that correlate with the antischizophrenic activity of phenothiazine drugs.氯丙嗪与多巴胺：与吩噻嗪类药物抗精神分裂症活性相关的构象相似性。
Proc Natl Acad Sci U S A. 1971 Oct;68(10):2325-8. doi: 10.1073/pnas.68.10.2325.
7
Physiologic and clinical effects of chlorpromazine and their relationship to plasma level.氯丙嗪的生理和临床效应及其与血浆水平的关系。
Clin Pharmacol Ther. 1972 Nov-Dec;13(6):931-46. doi: 10.1002/cpt1972136931.
8
The possible role of metabolites in therapeutic response to chlorpromazine treatment.代谢物在氯丙嗪治疗反应中的可能作用。
Psychopharmacologia. 1973 Sep 28;32(3):279-84. doi: 10.1007/BF00422150.
9
Effects of mode of management on plasma chlorpromazine in psychiatric patients.管理方式对精神科患者血浆氯丙嗪的影响。
Clin Pharmacol Ther. 1973 Nov-Dec;14(6):978-86. doi: 10.1002/cpt1973146978.
10
The dopamine hypothesis of schizophrenia: focus on the dopamine receptor.精神分裂症的多巴胺假说：聚焦于多巴胺受体。
Am J Psychiatry. 1976 Feb;133(2):197-202. doi: 10.1176/ajp.133.2.197.
Zotero 插件