英国、日本及日裔夏威夷女性的血浆免疫球蛋白A、免疫球蛋白G和免疫球蛋白M及其与乳腺癌的关系。

Plasma IgA, IgG and IgM and their relationship to breast cancer in British, Japanese and Hawaiian-Japanese women.

作者信息

Wang D Y, Goodwin P R, Bulbrook R D, Hayward J L, Abe O, Utsunomiya J, Kumaoka S, Greenwood F C, Glober G, Stemmerman G

出版信息

Cancer. 1979 Aug;44(2):492-4. doi: 10.1002/1097-0142(197908)44:2<492::aid-cncr2820440219>3.0.co;2-v.

DOI:10.1002/1097-0142(197908)44:2<492::aid-cncr2820440219>3.0.co;2-v

Abstract

The plasma levels of immunoglobulins IgA, IgG and IgM have been measured in 35 British, 44 Hawaiian-Japanese and 37 Japanese healthy adult women. Previous investigations showed that the mean levels of all three immunoglobulins were higher in Japanese than in British normal women. The present study finds that Hawaiian-Japanese women have "Japanese" levels of IgA, "British" levels of IgM and are intermediate for IgG. Thus, plasma IgM concentrations correlate with breast cancer incidence rates in the three racial groups and the reduced amounts of plasma IgM found in Japanese patients with breast cancer support this association.

摘要

已对35名英国、44名夏威夷日裔和37名日本健康成年女性的免疫球蛋白IgA、IgG和IgM的血浆水平进行了测量。先前的研究表明，所有这三种免疫球蛋白的平均水平在日本正常女性中高于英国正常女性。本研究发现，夏威夷日裔女性的IgA水平为“日本”水平，IgM水平为“英国”水平，IgG水平处于中间。因此，血浆IgM浓度与这三个种族群体的乳腺癌发病率相关，并且在日本乳腺癌患者中发现的血浆IgM量减少支持了这种关联。