乳腺癌中的局部免疫球蛋白产生
Local immunoglobulin production in breast cancer.
作者信息
Roberts M M, Bass E M, Wallace I W, Stevenson A
出版信息
Br J Cancer. 1973 Apr;27(4):269-75. doi: 10.1038/bjc.1973.33.
Abstract
Immunoglobulin levels (IgA, IgG, IgM) have been estimated in protein extracts of 55 malignant and 20 benign tumours of the breast, and in 17 normal tissues from a cancer bearing breast. IgA and IgG were significantly reduced in cancer compared with both benign and normal tissues but IgM, detected in only a third of tumours, was significantly increased. Total immunoglobulin levels and IgG in the malignant tumours correlated with plasma cell infiltration.The menstrual status of the patient had no influence on these findings.
摘要
已对55例乳腺恶性肿瘤、20例乳腺良性肿瘤以及取自患癌乳房的17份正常组织的蛋白质提取物中的免疫球蛋白水平（IgA、IgG、IgM）进行了评估。与良性和正常组织相比，癌症组织中的IgA和IgG显著降低，但仅在三分之一的肿瘤中检测到的IgM显著升高。恶性肿瘤中的总免疫球蛋白水平和IgG与浆细胞浸润相关。患者的月经状态对这些结果没有影响。
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