Kawai T, Salvaggio J, Harris J O, Arquembourg P
Clin Exp Immunol. 1973 Sep;15(1):123-30.
Intratracheal immunization of rabbits with , a thermophilic actinomycete known to be a rich source of `farmer's lung hay' antigen leads to development of pulmonary lesions similar to those noted in human hypersensitivity pneumonitis and in antigen induced MIF production by sensitized respiratory tract lymphocytes. MIF release was not specific for the respiratory route of immunization since immunization via the toe pad route using Freund's adjuvant also resulted in antigen induced migration inhibition of alveolar wash cells. If macrophage migration inhibition can be regarded as an correlate of cell mediated (type IV) hypersensitivity, our results suggest that this type of hypersensitivity plays a role in pathogenesis of experimentally induced hypersensitivity pneumonitis.
用一种嗜热放线菌对兔子进行气管内免疫，该嗜热放线菌是已知的“农民肺干草”抗原的丰富来源，这会导致肺部病变的发展，类似于人类过敏性肺炎以及致敏呼吸道淋巴细胞在抗原诱导下产生巨噬细胞移动抑制因子（MIF）时所观察到的病变。MIF的释放并非免疫呼吸道途径所特有的，因为使用弗氏佐剂通过足垫途径免疫也会导致抗原诱导的肺泡灌洗细胞迁移抑制。如果巨噬细胞迁移抑制可被视为细胞介导的（IV型）超敏反应的一个相关指标，那么我们的结果表明，这种类型的超敏反应在实验性诱导的过敏性肺炎发病机制中起作用。
