Silverstrini R, Daidone M G, Di Fronzo G
Cancer. 1979 Aug;44(2):665-70. doi: 10.1002/1097-0142(197908)44:2<665::aid-cncr2820440237>3.0.co;2-n.
The proliferative activity of breast cancer has been analyzed in relation to the hormonal characteristics of the host and of the tumor for 199 patients. The analyses of labeling index frequency distributions of estrogen receptor positive (ER+) and negative (ER-) cancers from premenopausal and postmenopausal patients have allowed us to identify three different kinetic groups. A first group, with a very low proliferative activity, includes ER+ cancers from postmenopausal patients; a second group, with an intermediate proliferative activity, includes ER+ cancers from premenopausal and ER- cancers from postmenopausal patients; and a third group, with a very high proliferative activity, includes ER- cancers from premenopausal patients. Generally, the amount of estrogen receptors in ER+ cancers is inversely correlated with the proliferative activity. Lower levels of ER in premenopausal in comparison to postmenopausal patients were found in low proliferative activity tumors.
针对199例患者，分析了乳腺癌的增殖活性与宿主及肿瘤激素特征之间的关系。通过对绝经前和绝经后患者雌激素受体阳性（ER+）和阴性（ER-）癌症的标记指数频率分布分析，我们确定了三个不同的动力学组。第一组增殖活性非常低，包括绝经后患者的ER+癌症；第二组增殖活性中等，包括绝经前患者的ER+癌症和绝经后患者的ER-癌症；第三组增殖活性非常高，包括绝经前患者的ER-癌症。一般来说，ER+癌症中雌激素受体的数量与增殖活性呈负相关。在增殖活性低的肿瘤中，发现绝经前患者的ER水平低于绝经后患者。
