van Bogaert L J, de Muylder C, Maldague P, Maisin H
Br J Cancer. 1980 Oct;42(4):537-41. doi: 10.1038/bjc.1980.277.
The mean nuclear diameter of 100 breast cancers was measured on tissue sections, to evaluate its importance for early prognosis. The cases were subdivided into 3 subgroups: small (25.5% of cases), medium (63.3%) and large (11.2%) nuclei. Early recurrence and mortality rates were investigated in each of the categories. Increasing nuclear size was shown to be related to mortality from metastatic disease. However, large-nucleus tumours had an inverse relationship with lymphnode involvement and possibly with recurrence rate. Hence, in our material nuclear size as a sole criterion was not a good indicator of the early behaviour of operable breast cancer.
在组织切片上测量了100例乳腺癌的平均核直径，以评估其对早期预后的重要性。这些病例被分为3个亚组：小核（占病例的25.5%）、中核（63.3%）和大核（11.2%）。对每个类别中的早期复发率和死亡率进行了调查。结果显示，核大小增加与转移性疾病导致的死亡率相关。然而，大核肿瘤与淋巴结受累呈负相关，可能也与复发率呈负相关。因此，在我们的研究材料中，仅将核大小作为标准并不是可手术乳腺癌早期行为的良好指标。
