Truhaut R, Ferrando R
Toxicology. 1975;3(3):361-8. doi: 10.1016/0300-483x(75)90037-2.
Chemical substances added for various purposes to the feeds of farm-reared animals may enter the body of these animals. This may lead to the persistence, in food offered for human consumption, of residues which may be potentially toxic under conditions of repeated absorption over the greater part of the life span. The evaluation of the safety of these residues for man poses complex problems. Their ideal solution demands very often a number of careful experiments. The methodology called "toxicity by relay" consists essentially of the submission of the animal feed itself, which is likely to contain a mosaic of residues, to long-term testing in laboratory animals. Provided a satisfactory safety factor can be applied, this methodology can contribute information permittinga conclusion regarding the acceptablity, even provisionally, of the feed additive for the use which is envisaged. In addition this methodology enables the provision of results constituting a criterion for the rejection of the additive under test. For these reasons it appears to us an appropriate procedure, taking its place among the tests to be undertaken for the toxicological evaluation of additves to the feeds of farm-reared animals.
出于各种目的添加到农场养殖动物饲料中的化学物质可能会进入这些动物体内。这可能导致供人类食用的食物中残留这些物质，在动物大部分生命周期内反复摄入的情况下，这些残留可能具有潜在毒性。评估这些残留物对人类的安全性会带来复杂问题。其理想的解决方案往往需要进行一系列细致的实验。所谓的“接力毒性”方法主要是将可能含有多种残留成分的动物饲料本身用于实验动物的长期测试。如果能够应用令人满意的安全系数，这种方法可以提供相关信息，以便就所设想用途的饲料添加剂是否可接受（即使是暂时的）得出结论。此外，这种方法能够提供结果，作为拒绝所测试添加剂的标准。基于这些原因，在我们看来，这是一个合适的程序，在对农场养殖动物饲料添加剂进行毒理学评估所需开展的测试中占有一席之地。
