Börzönyi B, Ferencz A, Surján A, Pintér A, Nádasdi I, Roller P P, Török G, Kiss K
Cancer Lett. 1979 Jul;7(2-3):135-9. doi: 10.1016/s0304-3835(79)80108-1.
Pyridinol carbamate was nitrosated to the N,N1-dinitroso derivative and the structure was proved by spectroscopic methods, including chemical ionization mass spectroscopy. By the Ames test, the dinitroso derivative showed a significant dose-dependent mutagenic response with Salmonella typhimurium strains TA 1535 and TA 100; the response became more pronounced in the presence of microsomes. As the dosage of N-nitroso pyridinol carbamate increased, the number of revertant colonies also increased. Pyridinol carbamate was not mutagenic.
氨基甲酸吡啶醇被亚硝化生成N,N1-二亚硝基衍生物，其结构通过光谱方法得以证实，包括化学电离质谱法。通过艾姆斯试验，二亚硝基衍生物对鼠伤寒沙门氏菌TA 1535和TA 100菌株表现出显著的剂量依赖性诱变反应；在微粒体存在的情况下，这种反应更为明显。随着N-亚硝基氨基甲酸吡啶醇剂量的增加，回复突变菌落的数量也增加。氨基甲酸吡啶醇没有致突变性。
