脂肪族亚硝胺在鼠伤寒沙门氏菌中的诱变性。
Mutagenicity of aliphatic nitrosamines in Salmonella typhimurium.
作者信息
Rao T K, Young J A, Lijinsky W, Epler J L
出版信息
Mutat Res. 1979 Jan;66(1):1-7. doi: 10.1016/0165-1218(79)90002-8.
PMID:370582
Abstract
25 aliphatic nitrosamines were examined in the Ames assay for bacterial mutagens, using rat liver "S-9" for activation. Of them, 8 carcinogens were mutagenic and 5 non-carcinogens were not mutagenic. However, 2 compounds not carcinogenic in rats were mutagenic and 9 carcinogens were not mutagenic, including 6 that are liver carcinogens in rats.
摘要
在艾姆斯氏试验中，使用大鼠肝脏“S - 9”进行活化，检测了25种脂肪族亚硝胺的细菌致突变性。其中，8种致癌物具有致突变性，5种非致癌物不具有致突变性。然而，2种在大鼠中不致癌的化合物具有致突变性，9种致癌物不具有致突变性，其中包括6种在大鼠中为肝脏致癌物的化合物。
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