Urano M, Montoya V, Booth A
Cancer Res. 1983 Feb;43(2):453-5.
The effect of an i.p. injection of glucose on the thermal response of murine tissues was studied. Animal tumors were early generation isotransplants of a spontaneous fibrosarcoma, FSa-II. Tumors were transplanted into the foot pad, and hyperthermia was given by immersing the foot into a constant-temperature water bath. The tumor and normal tissue responses were studied by assays of the time required for half the tumors to reach 1000 cu mm from treatment day and of the treatment time required for one-half of the animals to develop a loss of one toe or greater reaction. The glucose administration enhanced tumor response more substantially than normal tissue response. The enhancement was greater for a large tumor than for a small tumor and also greater at 42.0 degrees than at 45.5 degrees. Presumably, the hyperglycemia induced acidosis which eventually enhanced thermal response. Present results suggested that the hyperglycemia is a potential method to specifically enhance tumor response at elevated temperatures.
研究了腹腔注射葡萄糖对小鼠组织热反应的影响。动物肿瘤为自发性纤维肉瘤FSa-II的早期同基因移植瘤。将肿瘤移植到足垫，通过将足部浸入恒温水浴中来进行热疗。通过测定从治疗日起半数肿瘤达到1000立方毫米所需的时间以及半数动物出现一个或多个脚趾丧失或更严重反应所需的治疗时间，来研究肿瘤和正常组织的反应。给予葡萄糖对肿瘤反应的增强作用比对正常组织反应的增强作用更显著。大肿瘤的增强作用比小肿瘤更大，且在42.0摄氏度时比在45.5摄氏度时更大。据推测，高血糖诱导酸中毒，最终增强热反应。目前的结果表明，高血糖是一种在高温下特异性增强肿瘤反应的潜在方法。
