Milas L
Dev Biol Stand. 1977;38:301-6.
The effects of intravenous C. parvum (CP) on the efficacy of fractionated gamma-irradiation in treating a fairly immunogenic fibrosarcoma (FSa) and a weakly immunogenic mammary carcinoma (MDAH-MCa-4) were studied in C3Hf/Bu mice. Tumors were 8 mm in diameter at the start of irradiation. The FSa was exposed to 500 and the MDAH-MCa-4 to 750 rads daily for 3.6 or 10 days. The administration of 0.25 mg CP varied from 4 days before to 14 days after the start of irradiation. CP greatly augmented radiocurability of FSa, especially when applied before irradiation. The effect was evidenced by the increase in the cure rate, and, in mice not cured, by the tumor growth retardation, reduction of pulmonary metastasis incidence and prolongation in survival of mice. This effect of i.v. CP on FSa radiocurability was not further increased by intralesional CP, or by systemic injections of vitamin A or the hypoxic tumor cell radiosensitizer Ro-07-0582. CP was less effective in augmenting radiation response of the MDAH-MCa-4. Here, CP slowed the growth of irradiated tumors and prolonged the survival of mice.
在C3Hf/Bu小鼠中研究了静脉注射微小隐孢子虫（CP）对分次γ射线照射治疗具有相当免疫原性的纤维肉瘤（FSa）和弱免疫原性的乳腺癌（MDAH-MCa-4）疗效的影响。在开始照射时肿瘤直径为8毫米。FSa每天接受500拉德照射，MDAH-MCa-4每天接受750拉德照射，持续3.6天或10天。0.25毫克CP的给药时间从照射开始前4天至照射开始后14天不等。CP显著增强了FSa的放射治愈率，尤其是在照射前应用时。治愈率的提高证明了这种效果，在未治愈的小鼠中，肿瘤生长延迟、肺转移发生率降低以及小鼠存活期延长也证明了这种效果。静脉注射CP对FSa放射治愈率的这种作用，通过瘤内注射CP、全身注射维生素A或缺氧肿瘤细胞放射增敏剂Ro-07-0582并未进一步增强。CP在增强MDAH-MCa-4的放射反应方面效果较差。在此，CP减缓了照射后肿瘤的生长并延长了小鼠的存活期。
