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生长抑素对类癌综合征患者生长激素和催乳素异常分泌的影响。

Effect of somatostatin on abnormal growth hormone and prolactin secretion in patients with the carcinoid syndrome.

作者信息

Gomez-Pan A, Scanlon M F, Thorner M O, Rees L H, Schally A V, Hall R, Besser G M

出版信息

Clin Endocrinol (Oxf). 1979 Jun;10(6):575-81. doi: 10.1111/j.1365-2265.1979.tb02117.x.

DOI:10.1111/j.1365-2265.1979.tb02117.x
PMID:476984
Abstract

Growth hormone (GH) secretion has been studied in two patients with the carcinoid syndrome during glucose loading and growth hormone-release inhibiting hormone (GHRIH, somatostatin) infusion. Both patients had elevated fasting GH levels which were not suppressed by glucose; GH levels fell rapidly during GHRIH infusion. One patient also had hyperprolactinaemia with galactorrhoea and the prolactin (PRL) levels were unaltered by GHRIH. The association between carcinoid tumours and abnormalities of GH and PRL secretion is discussed.

摘要

对两名类癌综合征患者在葡萄糖负荷及输注生长抑素期间的生长激素(GH)分泌情况进行了研究。两名患者空腹GH水平均升高,且未被葡萄糖抑制;在输注生长抑素期间,GH水平迅速下降。其中一名患者还伴有高泌乳素血症及溢乳,其泌乳素(PRL)水平不受生长抑素影响。本文讨论了类癌肿瘤与GH及PRL分泌异常之间的关联。

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Clin Endocrinol (Oxf). 1979 Jun;10(6):575-81. doi: 10.1111/j.1365-2265.1979.tb02117.x.
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引用本文的文献

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Front Endocrinol (Lausanne). 2022 Jun 9;13:867965. doi: 10.3389/fendo.2022.867965. eCollection 2022.
2
Circulating growth hormone releasing factor concentrations in normal subjects and patients with acromegaly.正常受试者和肢端肥大症患者的循环生长激素释放因子浓度。
Br Med J (Clin Res Ed). 1984 Aug 25;289(6443):453-5. doi: 10.1136/bmj.289.6443.453.
3
Some current aspects of clinical and experimental neuroendocrinology with particular reference to growth hormone, thyrotropin and prolactin.
临床与实验神经内分泌学的一些当前研究方面,特别涉及生长激素、促甲状腺激素和催乳素。
J Endocrinol Invest. 1979 Jul-Sep;2(3):307-31. doi: 10.1007/BF03350424.