Gomez-Pan A, Scanlon M F, Thorner M O, Rees L H, Schally A V, Hall R, Besser G M
Clin Endocrinol (Oxf). 1979 Jun;10(6):575-81. doi: 10.1111/j.1365-2265.1979.tb02117.x.
Growth hormone (GH) secretion has been studied in two patients with the carcinoid syndrome during glucose loading and growth hormone-release inhibiting hormone (GHRIH, somatostatin) infusion. Both patients had elevated fasting GH levels which were not suppressed by glucose; GH levels fell rapidly during GHRIH infusion. One patient also had hyperprolactinaemia with galactorrhoea and the prolactin (PRL) levels were unaltered by GHRIH. The association between carcinoid tumours and abnormalities of GH and PRL secretion is discussed.
对两名类癌综合征患者在葡萄糖负荷及输注生长抑素期间的生长激素(GH)分泌情况进行了研究。两名患者空腹GH水平均升高,且未被葡萄糖抑制;在输注生长抑素期间,GH水平迅速下降。其中一名患者还伴有高泌乳素血症及溢乳,其泌乳素(PRL)水平不受生长抑素影响。本文讨论了类癌肿瘤与GH及PRL分泌异常之间的关联。