肺出血肾炎综合征——血浆置换的效果
Goodpasture's syndrome--effects of plasmapheresis.
作者信息
Munk Z M, Skamene E
出版信息
Clin Exp Immunol. 1979 May;36(2):244-9.
Abstract
Two patients with Goodpasture's syndrome, who underwent plasmapheresis are presented. One patient received prednisone but the other patient received no concomitant cytotoxic therapy. Results indicate that plasmapheresis reduces morbidity in patients with Goodpasture's syndrome. The possible mode of action of plasmapheresis is discussed. The use of cytotoxic therapy as an adjunct to plasmapheresis may not be necessary since the anti-GBM production appears to be a self-limiting process.
摘要
本文报告了两名患有古德帕斯彻综合征且接受了血浆置换的患者。一名患者接受了泼尼松治疗，而另一名患者未接受伴随的细胞毒性治疗。结果表明，血浆置换可降低古德帕斯彻综合征患者的发病率。本文讨论了血浆置换可能的作用方式。由于抗肾小球基底膜的产生似乎是一个自限性过程，因此可能无需将细胞毒性治疗作为血浆置换的辅助手段。
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本文引用的文献
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Regulation of antibody formation by serum antibody. II. Removal of specific antibody by means of exchange transfusion.血清抗体对抗体形成的调节。II. 通过换血去除特异性抗体。
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Treatment of Goodpasture syndrome with cyclophosphamide, prednisone and plasma exchange transfusions.用环磷酰胺、泼尼松和血浆置换输血治疗肺出血肾炎综合征。
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Plasmapheresis and immunosuppressive agents in antibasement membrane antibody-induced Goodpasture's syndrome.血浆置换及免疫抑制剂治疗抗基底膜抗体诱发的肺出血肾炎综合征
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Immunosuppression and plasma-exchange in the treatment of Goodpasture's syndrome.免疫抑制和血浆置换治疗肺出血肾炎综合征
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