Rossen R D, Duffy J, McCredie K B, Reisberg M A, Sharp J T, Hersh E M, Eknoyan G, Suki W N
Clin Exp Immunol. 1976 Apr;24(1):218-22.
Repeated plasm exchanges were performed in a 44-year-old man with Goodpasture syndrome, also treated with cyclophosphamide and prednisone. Improvement was observed within 3 weeks of starting the protocol, and by the 76th week, endogenous creatinine clearance had increased from 30 to 56 ml/min/1.73 M2 and serum albumin from 2.7 to 3.7 g/dl. Prior treatment with immunosuppressive drugs had not significantly influenced circulating antibody levels. But sustained suppression of antibody was achieved after the plasma exchanges were begun, suggesting that physical removal of circulating antibody combined with antiproliferative drug treatment may be a useful way to control undesirable humoral immune responses.
对一名患有古德帕斯彻综合征的44岁男性进行了重复血浆置换，同时还接受了环磷酰胺和泼尼松治疗。在开始该方案的3周内观察到病情改善，到第76周时，内生肌酐清除率从30 ml/min/1.73 M2提高到56 ml/min/1.73 M2，血清白蛋白从2.7 g/dl提高到3.7 g/dl。先前使用免疫抑制药物治疗对循环抗体水平没有显著影响。但在开始血浆置换后实现了抗体的持续抑制，这表明物理去除循环抗体与抗增殖药物治疗相结合可能是控制不良体液免疫反应的一种有效方法。
