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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Grace S A, Munday K A, Noble A R, Richards H K

J Physiol. 1979 Jul;292:421-8. doi: 10.1113/jphysiol.1979.sp012861.

Active and acid-activatable (inactive) renins were measured in rabbit plasma under control conditions and during sodium depletion with subsequent repletion. 2. Active renin increased by 97% during sodium depletion and returned to control levels on repletion. Both changes were complete within 1 day of changing the diet. 3. During dietary sodium depletion inactive renin levels initially fell to zero and then increased until, after 13 days, inactive renin was again 10% of total renin levels, a proportion comparable to the control values. 4. Sodium repletion caused plasma inactive renin to return to control levels over about 13 days, a quite different time course to active renin. Therefore, in the first phase of repletion the proportion of total renin in the inactive form rose to 19%. 5. These changes are discussed in relation to concurrent changes in sodium, potassium and water metabolism.

在对照条件下以及钠耗竭并随后补充钠的过程中，对兔血浆中的活性肾素和酸可激活（无活性）肾素进行了测定。2. 钠耗竭期间活性肾素增加了97%，补充钠后恢复到对照水平。这两种变化在改变饮食后1天内完成。3. 在饮食性钠耗竭期间，无活性肾素水平最初降至零，然后升高，直到13天后，无活性肾素再次占总肾素水平的10%，这一比例与对照值相当。4. 补充钠导致血浆无活性肾素在约13天内恢复到对照水平，这与活性肾素的时间进程截然不同。因此，在补充的第一阶段，无活性形式的总肾素比例上升至19%。5. 结合钠、钾和水代谢的同时变化对这些变化进行了讨论。

Grace S A, Munday K A, Noble A R, Richards H K

J Physiol. 1979 Jul;292:421-8. doi: 10.1113/jphysiol.1979.sp012861.

Active and acid-activatable (inactive) renins were measured in rabbit plasma under control conditions and during sodium depletion with subsequent repletion. 2. Active renin increased by 97% during sodium depletion and returned to control levels on repletion. Both changes were complete within 1 day of changing the diet. 3. During dietary sodium depletion inactive renin levels initially fell to zero and then increased until, after 13 days, inactive renin was again 10% of total renin levels, a proportion comparable to the control values. 4. Sodium repletion caused plasma inactive renin to return to control levels over about 13 days, a quite different time course to active renin. Therefore, in the first phase of repletion the proportion of total renin in the inactive form rose to 19%. 5. These changes are discussed in relation to concurrent changes in sodium, potassium and water metabolism.

在对照条件下以及钠耗竭并随后补充钠的过程中，对兔血浆中的活性肾素和酸可激活（无活性）肾素进行了测定。2. 钠耗竭期间活性肾素增加了97%，补充钠后恢复到对照水平。这两种变化在改变饮食后1天内完成。3. 在饮食性钠耗竭期间，无活性肾素水平最初降至零，然后升高，直到13天后，无活性肾素再次占总肾素水平的10%，这一比例与对照值相当。4. 补充钠导致血浆无活性肾素在约13天内恢复到对照水平，这与活性肾素的时间进程截然不同。因此，在补充的第一阶段，无活性形式的总肾素比例上升至19%。5. 结合钠、钾和水代谢的同时变化对这些变化进行了讨论。