关于异烟肼+丙硫异烟胺+氨苯砜（Isoprodian）抗分枝杆菌活性的机制
On the mechanism of the antimycobacterial activity of isoniazid + prothionamide + dapsone (Isoprodian).
作者信息
Urbanczik R
出版信息
Chemotherapy. 1979;25(5):261-7. doi: 10.1159/000237849.
Increased antimycobacterial activity of Isoprodian (isoniazid + prothionamide + dapsone) may be due to (i) decreased mutation rate for INH resistance provoked in mycobacteria by DDS (in 2 of 3 strains tested); (ii) leakage of K+, Na+ or Ca++ caused by INH and/or by PTH (in all 3 strains tested), and (iii) indicating damages which may increase the low level penetration of DDS into the cell in sub-MIC concentrations as shown by phage proliferation changes (tested in 1 strain with 1 phage).
异烟肼-丙硫异烟胺-氨苯砜（Isoprodian）抗分枝杆菌活性增强可能是由于：（i）氨苯砜（DDS）引发的分枝杆菌对异烟肼（INH）耐药的突变率降低（在3株受试菌株中的2株）；（ii）异烟肼和/或丙硫异烟胺（PTH）导致钾离子、钠离子或钙离子泄漏（在所有3株受试菌株中）；以及（iii）如噬菌体增殖变化所示（在1株菌株中用1种噬菌体进行测试），表明损伤可能会增加亚抑菌浓度下氨苯砜进入细胞的低水平渗透。
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