Kinnman J, Link H, Frydén A
Eur Neurol. 1979;18(3):189-93. doi: 10.1159/000115075.
The effect of phytohemagglutinin (PHA) and pokeweed mitogen (PWM) on blood lymphocytes was studied in multiple sclerosis, patients with acute CNS infections, and healthy controls. No significant differences in lymphocyte proliferation were registered between the group of MS patients and the two other groups, irrespective of mitogen used. The ratio between the PWM and PHA responses did not differ significantly from the ratios in the two other groups. The lymphocyte proliferation with PWM was significantly lower in the group with acute CNS infections compared with controls. The results indicate that alterations in cell-mediated immunity, if present in MS, are not confined to lymphocytes outside the CNS.
在多发性硬化症患者、急性中枢神经系统感染患者和健康对照者中，研究了植物血凝素（PHA）和商陆有丝分裂原（PWM）对血液淋巴细胞的影响。无论使用何种有丝分裂原，多发性硬化症患者组与其他两组之间在淋巴细胞增殖方面均未发现显著差异。PWM与PHA反应的比率与其他两组的比率没有显著差异。与对照组相比，急性中枢神经系统感染组中PWM诱导的淋巴细胞增殖显著降低。结果表明，细胞介导的免疫改变（如果在多发性硬化症中存在）并不局限于中枢神经系统外的淋巴细胞。
